Michael L Hutton
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Explore the profile of Michael L Hutton including associated specialties, affiliations and a list of published articles.
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41
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3358
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Recent Articles
11.
DeMattos R, Lu J, Tang Y, Racke M, Delong C, Tzaferis J, et al.
Neuron
. 2012 Dec;
76(5):908-20.
PMID: 23217740
Aβ Immunotherapy is a promising therapeutic approach for Alzheimer's disease. Preclinical studies demonstrate that plaque prevention is possible; however, the more relevant therapeutic removal of existing plaque has proven elusive....
12.
Chai X, Wu S, Murray T, Kinley R, Cella C, Sims H, et al.
J Biol Chem
. 2011 Aug;
286(39):34457-67.
PMID: 21841002
The microtubule-associated protein Tau plays a critical role in the pathogenesis of Alzheimer disease and several related disorders (tauopathies). In the disease Tau aggregates and becomes hyperphosphorylated forming paired helical...
13.
Webster J, Reiman E, Zismann V, Joshipura K, Pearson J, Hu-Lince D, et al.
Int J Mol Epidemiol Genet
. 2011 May;
1(1):19-30.
PMID: 21537449
For late onset Alzheimer's disease (LOAD), the only confirmed, genetic association is with the apolipoprotein E (APOE) locus on chromosome 19. Meta-analysis is often employed to sort the true associations...
14.
Ahmed Z, Sheng H, Xu Y, Lin W, Innes A, Gass J, et al.
Am J Pathol
. 2010 Jun;
177(1):311-24.
PMID: 20522652
Progranulin (PGRN) is involved in wound repair, inflammation, and tumor formation, but its function in the central nervous system is unknown. Roles in development, sexual differentiation, and long-term neuronal survival...
15.
Tatom J, Wang D, Dayton R, Skalli O, Hutton M, Dickson D, et al.
Mol Ther
. 2009 Feb;
17(4):607-13.
PMID: 19223871
Since the discovery of neuropathological lesions made of TDP-43 and ubiquitin proteins in cases of frontotemporal lobar degeneration (FTLD) and amyotrophic lateral sclerosis (ALS), there is a burst of effort...
16.
Corneveaux J, Liang W, Reiman E, Webster J, Myers A, Zismann V, et al.
Neurobiol Aging
. 2008 Sep;
31(6):901-9.
PMID: 18789830
We recently reported evidence for an association between the individual variation in normal human episodic memory and a common variant of the KIBRA gene, KIBRA rs17070145 (T-allele). Since memory impairment...
17.
Rademakers R, Eriksen J, Baker M, Robinson T, Ahmed Z, Lincoln S, et al.
Hum Mol Genet
. 2008 Aug;
17(23):3631-42.
PMID: 18723524
Loss-of-function mutations in progranulin (GRN) cause ubiquitin- and TAR DNA-binding protein 43 (TDP-43)-positive frontotemporal dementia (FTLD-U), a progressive neurodegenerative disease affecting approximately 10% of early-onset dementia patients. Here we expand...
18.
Rudzinski L, Fletcher R, Dickson D, Crook R, Hutton M, Adamson J, et al.
Alzheimer Dis Assoc Disord
. 2008 Jun;
22(3):299-307.
PMID: 18580586
Objective: Early onset familial Alzheimer disease (EOFAD) can be caused by mutations in genes for amyloid precursor protein, presenilin 1 (PSEN1), or presenilin 2 (PSEN2). There is considerable phenotypic variability...
19.
Wider C, Uitti R, Wszolek Z, Fang J, Josephs K, Baker M, et al.
Mov Disord
. 2008 Apr;
23(8):1168-73.
PMID: 18442119
Progranulin gene (PGRN) mutations cause frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U). Patients usually present with a frontotemporal dementia syndrome and have prominent atrophy and neuronal loss in frontal and...
20.
Sando S, Melquist S, Cannon A, Hutton M, Sletvold O, Saltvedt I, et al.
BMC Neurol
. 2008 Apr;
8:9.
PMID: 18416843
Background: The objective of this study was to analyze factors influencing the risk and timing of Alzheimer's disease (AD) in central Norway. The APOE epsilon4 allele is the only consistently...