Michael L Barta
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Explore the profile of Michael L Barta including associated specialties, affiliations and a list of published articles.
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24
Citations
301
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Recent Articles
1.
Composition and Biophysical Properties of the Sorting Platform Pods in the Type III Secretion System
Tachiyama S, Skaar R, Chang Y, Carroll B, Muthuramalingam M, Whittier S, et al.
Front Cell Infect Microbiol
. 2021 Jun;
11:682635.
PMID: 34150677
, causative agent of bacillary dysentery (shigellosis), uses a type III secretion system (T3SS) as its primary virulence factor. The T3SS injectisome delivers effector proteins into host cells to promote...
2.
Tachiyama S, Chang Y, Muthuramalingam M, Hu B, Barta M, Picking W, et al.
J Biol Chem
. 2019 Nov;
294(50):19184-19196.
PMID: 31699894
Many Gram-negative bacteria use type III secretion systems (T3SSs) to inject virulence effector proteins into eukaryotic cells. The T3SS apparatus (T3SA) is structurally conserved among diverse bacterial pathogens and consists...
3.
Picking W, Barta M
Curr Top Microbiol Immunol
. 2019 Jun;
427:173-199.
PMID: 31218507
Type III secretion systems are used by some Gram-negative bacteria to inject effector proteins into targeted eukaryotic cells for the benefit of the bacterium. The type III secretion injectisome is...
4.
Cosse M, Barta M, Fisher D, Oesterlin L, Niragire B, Perrinet S, et al.
Front Cell Infect Microbiol
. 2018 Jun;
8:145.
PMID: 29868501
Invasion of epithelial cells by the obligate intracellular bacterium results in its enclosure inside a membrane-bound compartment termed an inclusion. The bacterium quickly begins manipulating interactions between host intracellular trafficking...
5.
Barta M, Tachiyama S, Muthuramalingam M, Arizmendi O, Villanueva C, Ramyar K, et al.
Protein Sci
. 2018 Apr;
27(8):1392-1406.
PMID: 29672980
Bacterial type III secretion systems (T3SS) are used to inject proteins into mammalian cells to subvert cellular functions. The Shigella T3SS apparatus (T3SA) is comprised of a basal body, cytoplasmic...
6.
Barta M, Shearer J, Arizmendi O, Tremblay J, Mehzabeen N, Zheng Q, et al.
J Biol Chem
. 2017 Aug;
292(40):16677-16687.
PMID: 28842484
Numerous Gram-negative pathogens infect eukaryotes and use the type III secretion system (T3SS) to deliver effector proteins into host cells. One important T3SS feature is an extracellular needle with an...
7.
Wei Y, Wahome N, VanSlyke G, Whitaker N, Kumar P, Barta M, et al.
Protein Sci
. 2017 Jul;
26(10):2059-2072.
PMID: 28736824
Polyvalent antigen display is an effective strategy to enhance the immunogenicity of subunit vaccines by clustering them in an array-like manner on a scaffold system. This strategy results in a...
8.
Barta M, Adam P, Dickenson N
Methods Mol Biol
. 2016 Nov;
1531:173-181.
PMID: 27837491
Type III secretion systems (T3SS) are highly conserved virulence factors employed by a large number of pathogenic gram-negative bacteria. Like many T3SS translocators, recombinant expression of the hydrophobic Shigella protein...
9.
Adam P, Barta M, Dickenson N
Methods Mol Biol
. 2016 Nov;
1531:81-91.
PMID: 27837483
In vitro characterization of type III secretion system (T3SS) translocator proteins has proven challenging due to complex purification schemes and their hydrophobic nature that often requires detergents to provide protein...
10.
Brothwell J, Muramatsu M, Toh E, Rockey D, Putman T, Barta M, et al.
J Bacteriol
. 2016 Jun;
198(15):2131-9.
PMID: 27246568
Unlabelled: Intracellular bacterial pathogens in the family Chlamydiaceae are causes of human blindness, sexually transmitted disease, and pneumonia. Genetic dissection of the mechanisms of chlamydial pathogenicity has been hindered by...