Kevin P Battaile
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Explore the profile of Kevin P Battaile including associated specialties, affiliations and a list of published articles.
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Articles
116
Citations
1968
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Recent Articles
1.
Jezewski A, Krysan D, Alden K, Daraji D, Lail 3rd C, Propp J, et al.
Res Sq
. 2025 Jan;
PMID: 39801522
Acetyl CoA synthetases (ACS) have emerged as drug targets for the treatment of cancer, metabolic diseases as well as fungal and parasitic infections. Although a variety of small molecule ACS...
2.
Srivastava A, Nair A, Dawson O, Gao R, Liu L, Craig J, et al.
Acta Crystallogr F Struct Biol Commun
. 2024 Nov;
PMID: 39601418
The unicellular parasitic protozoan Trichomonas vaginalis causes trichomoniasis, the most prevalent nonviral sexually transmitted disease globally. T. vaginalis evades host immune responses by producing homologs of host proteins, including cytokines...
3.
Andrade Meirelles M, Almeida V, Sullivan J, de Toledo I, Dos Reis C, Cunha M, et al.
J Med Chem
. 2024 Oct;
67(21):19143-19164.
PMID: 39468773
Nontuberculous mycobacteria (NTM) are emerging human pathogens linked to severe pulmonary diseases. Current treatments involve the prolonged use of multiple drugs and are often ineffective. Bacterial dihydrofolate reductase (DHFR) is...
4.
Hegde S, Akhter S, Tang Z, Qi C, Yu C, Lewicka A, et al.
bioRxiv
. 2024 Oct;
PMID: 39464119
Small-molecule RNA binders have emerged as an important pharmacological modality. A profound understanding of the ligand selectivity, binding mode, and influential factors governing ligand engagement with RNA targets is the...
5.
Myers M, Xu Z, Ryan B, DeMars Z, Ridder M, Johnson D, et al.
J Biol Chem
. 2024 Oct;
300(12):107920.
PMID: 39454961
Gram-positive bacteria utilize a Fatty Acid Kinase (FAK) complex to harvest fatty acids from the environment. This complex consists of the fatty acid kinase, FakA, and an acyl carrier protein,...
6.
Jezewski A, Esan T, Propp J, Fuller A, Daraji D, Lail 3rd C, et al.
J Biol Chem
. 2024 Oct;
300(11):107879.
PMID: 39395803
Leishmania, a protozoan parasite, is responsible for significant morbidity and mortality worldwide, manifesting as cutaneous, mucocutaneous, and visceral leishmaniasis. These diseases pose a substantial burden, especially in impoverished regions with...
7.
Murphy B, Wiepen J, Graham D, Swanson S, Kashipathy M, Cooper A, et al.
bioRxiv
. 2024 Aug;
PMID: 39149330
In diderm bacteria, the Lol pathway canonically mediates the periplasmic transport of lipoproteins from the inner membrane (IM) to the outer membrane (OM) and therefore plays an essential role in...
8.
Yao H, Alli S, Liu L, Soldano A, Cooper A, Fontenot L, et al.
Sci Rep
. 2024 Aug;
14(1):18242.
PMID: 39107474
Iron storage proteins, e.g., vertebrate ferritin, and the ferritin-like bacterioferritin (Bfr) and bacterial ferritin (Ftn), are spherical, hollow proteins that catalyze the oxidation of Fe at binuclear iron ferroxidase centers...
9.
Mahoney M, Helander J, Kooner A, Norman M, Damalanka V, De Bona P, et al.
Protein Sci
. 2024 Jul;
33(8):e5110.
PMID: 39073183
Inhibition of the proteolytic processing of hepatocyte growth factor (HGF) and macrophage stimulating protein (MSP) is an attractive approach for the drug discovery of novel anticancer therapeutics which prevent tumor...
10.
Kancherla A, Liu L, Tillery L, Shek R, Craig J, Machen A, et al.
Acta Crystallogr F Struct Biol Commun
. 2024 Jul;
80(Pt 8):173-182.
PMID: 38990055
Klebsiella pneumoniae (Kp) is an infectious disease pathogen that poses a significant global health threat due to its potential to cause severe infections and its tendency to exhibit multidrug resistance....