Michael J Romanowski
Overview
Explore the profile of Michael J Romanowski including associated specialties, affiliations and a list of published articles.
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Articles
34
Citations
675
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Recent Articles
1.
Visser M, Papillon J, Luzzio M, LaMarche M, Fan J, Michael W, et al.
J Med Chem
. 2024 Jan;
67(2):1447-1459.
PMID: 38198520
Uveal melanoma (UM) is the most common primary intraocular malignancy in the adult eye. Despite the aggressive local management of primary UM, the development of metastases is common with no...
2.
Remillard D, Savage N, Kedves A, Paulk J, Chen X, Garcia F, et al.
ACS Chem Biol
. 2021 Sep;
16(11):2185-2192.
PMID: 34515462
Bromodomain-containing proteins frequently reside in multisubunit chromatin complexes with tissue or cell state-specific compositions. Recent studies have revealed tumor-specific dependencies on the BAF complex bromodomain subunit BRD9 that are a...
3.
Hopkins B, Bame E, Bell N, Bohnert T, Bowden-Verhoek J, Bui M, et al.
Bioorg Med Chem
. 2021 Jul;
44:116275.
PMID: 34314938
Bruton's tyrosine kinase (BTK) is an essential node on the BCR signaling in B cells, which are clinically validated to play a critical role in B-cell lymphomas and various auto-immune...
4.
Jendza K, Kato M, Salcius M, Srinivas H, De Erkenez A, Nguyen A, et al.
Nat Chem Biol
. 2019 Jun;
15(7):666-668.
PMID: 31209353
The complement pathway is an important part of the immune system, and uncontrolled activation is implicated in many diseases. The human complement component 5 protein (C5) is a validated drug...
5.
Hopkins B, Bame E, Bell N, Bohnert T, Bowden-Verhoek J, Bui M, et al.
Bioorg Med Chem
. 2019 May;
27(13):2905-2913.
PMID: 31138459
Since the approval of ibrutinib for the treatment of B-cell malignancies in 2012, numerous clinical trials have been reported using covalent inhibitors to target Bruton's tyrosine kinase (BTK) for oncology...
6.
Arora R, Nimonkar A, Baird D, Wang C, Chiu C, Horton P, et al.
Proc Natl Acad Sci U S A
. 2019 May;
116(21):10360-10365.
PMID: 31072929
Lipoprotein lipase (LPL) plays a central role in triglyceride (TG) metabolism. By catalyzing the hydrolysis of TGs present in TG-rich lipoproteins (TRLs), LPL facilitates TG utilization and regulates circulating TG...
7.
Katoli P, Godbole A, Romanowski M, Clark K, Meredith E, Saenz-Vash V, et al.
Protein Expr Purif
. 2018 Feb;
147:38-48.
PMID: 29475084
Myocilin (MYOC) is a secreted protein found in human aqueous humor (AH) and mutations in the MYOC gene are the most common mutation observed in glaucoma patients. Human AH analyzed...
8.
Luksch H, Romanowski M, Chara O, Tungler V, Caffarena E, Heymann M, et al.
Hum Mutat
. 2012 Jul;
34(1):122-31.
PMID: 22833538
Caspase-1 (Interleukin-1 Converting Enzyme, ICE) is a proinflammatory enzyme that plays pivotal roles in innate immunity and many inflammatory conditions such as periodic fever syndromes and gout. Inflammation is often...
9.
Erlanson D, Arndt J, Cancilla M, Cao K, Elling R, English N, et al.
Bioorg Med Chem Lett
. 2011 Apr;
21(10):3078-83.
PMID: 21459573
We report the use of a fragment-based lead discovery method, Tethering with extenders, to discover a pyridinone fragment that binds in an adaptive site of the protein PDK1. With subsequent...
10.
Marcotte D, Liu Y, Arduini R, Hession C, Miatkowski K, Wildes C, et al.
Protein Sci
. 2010 Jan;
19(3):429-39.
PMID: 20052711
Bruton's tyrosine kinase (BTK), a member of the TEC family of kinases, plays a crucial role in B-cell maturation and mast cell activation. Although the structures of the unphosphorylated mouse...