Michael J Guertin
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Explore the profile of Michael J Guertin including associated specialties, affiliations and a list of published articles.
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36
Citations
1100
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Recent Articles
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Magnitov M, Maresca M, Alonso Saiz N, Teunissen H, Dong J, Sathyan K, et al.
Mol Cell
. 2024 Dec;
85(1):24-41.e11.
PMID: 39708805
Gene expression is orchestrated by transcription factors, which function within the context of a three-dimensional genome. Zinc-finger protein 143 (ZNF143/ZFP143) is a transcription factor that has been implicated in both...
3.
ZNF143 binds DNA and stimulates transcription initiation to activate and repress direct target genes
Dong J, Sathyan K, Scott T, Mukherjee R, Guertin M
Nucleic Acids Res
. 2024 Dec;
53(2.
PMID: 39676670
Transcription factors bind to sequence motifs and act as activators or repressors. Transcription factors interface with a constellation of accessory cofactors to regulate distinct mechanistic steps to regulate transcription. We...
4.
Dong J, Guertin M
Genes Dev
. 2024 Nov;
38(21-24):931-932.
PMID: 39505405
Notch signaling is a highly conserved pathway activated by dynamic cellular interactions that initiates a molecular cascade that ultimately drives changes in gene expression. The Notch transcriptional complex (NTC) regulates...
5.
Dong J, Scott T, Mukherjee R, Guertin M
bioRxiv
. 2024 May;
PMID: 38798607
Transcription factors bind to sequence motifs and act as activators or repressors. Transcription factors interface with a constellation of accessory cofactors to regulate distinct mechanistic steps to regulate transcription. We...
6.
Scott T, Sathyan K, Gioeli D, Guertin M
PLoS Genet
. 2024 Feb;
20(2):e1011159.
PMID: 38377146
Common genetic variants in the repressive GATA-family transcription factor (TF) TRPS1 locus are associated with breast cancer risk, and luminal breast cancer cell lines are particularly sensitive to TRPS1 knockout....
7.
Hasterok S, Scott T, Roller D, Spencer A, Dutta A, Sathyan K, et al.
Mol Cancer Res
. 2023 Sep;
21(12):1329-1341.
PMID: 37698543
Implications: Our data indicate that the clinical benefit of combining ADT with RT is not due to direct AR regulation of DDR gene transcription, and that the field needs to...
8.
Scott T, Sathyan K, Gioeli D, Guertin M
bioRxiv
. 2023 Jul;
PMID: 37461612
Breast cancer is the most frequently diagnosed cancer in women. The most common subtype is luminal breast cancer, which is typically driven by the estrogen receptor (ER), a transcription factor...
9.
Wolpe J, Martins A, Guertin M
NAR Genom Bioinform
. 2023 Jun;
5(2):lqad054.
PMID: 37274120
Chromatin accessibility assays have revolutionized the field of transcription regulation by providing single-nucleotide resolution measurements of regulatory features such as promoters and transcription factor binding sites. ATAC-seq directly measures how...
10.
Przanowski P, Przanowska R, Guertin M
Commun Biol
. 2023 Mar;
6(1):231.
PMID: 36859531
Alleles within the chr19p13.1 locus are associated with increased risk of both ovarian and breast cancer and increased expression of the ANKLE1 gene. ANKLE1 is molecularly characterized as an endonuclease...