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» Authors » Kizhakke Mattada Sathyan

Kizhakke Mattada Sathyan

Explore the profile of Kizhakke Mattada Sathyan including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 7
Citations 85
Followers 0
Related Specialties
Biology
Molecular Biology
Genetics
Top 10 Co-Authors
Michael J Guertin
Thomas G Scott
Daniel Gioeli
Leighton Core
Fabiana M Duarte
Jinhong Dong
Daniel R Foltz
Issam Ben-Sahra
Yalu Zhou
Nathan C Sheffield
Published In
Genes Dev
Genome Biol
Nucleic Acids Res
Curr Protoc Mol Biol
bioRxiv
Affiliations
Soon will be listed here.
Recent Articles
1.
ZNF143 binds DNA and stimulates transcription initiation to activate and repress direct target genes
Dong J, Sathyan K, Scott T, Mukherjee R, Guertin M
Nucleic Acids Res . 2024 Dec; 53(2. PMID: 39676670
Transcription factors bind to sequence motifs and act as activators or repressors. Transcription factors interface with a constellation of accessory cofactors to regulate distinct mechanistic steps to regulate transcription. We...
2.
TRPS1 modulates chromatin accessibility to regulate estrogen receptor alpha (ER) binding and ER target gene expression in luminal breast cancer cells
Scott T, Sathyan K, Gioeli D, Guertin M
PLoS Genet . 2024 Feb; 20(2):e1011159. PMID: 38377146
Common genetic variants in the repressive GATA-family transcription factor (TF) TRPS1 locus are associated with breast cancer risk, and luminal breast cancer cell lines are particularly sensitive to TRPS1 knockout....
3.
TRPS1 modulates chromatin accessibility to regulate estrogen receptor (ER) binding and ER target gene expression in luminal breast cancer cells
Scott T, Sathyan K, Gioeli D, Guertin M
bioRxiv . 2023 Jul; PMID: 37461612
Breast cancer is the most frequently diagnosed cancer in women. The most common subtype is luminal breast cancer, which is typically driven by the estrogen receptor (ER), a transcription factor...
4.
PEPPRO: quality control and processing of nascent RNA profiling data
Smith J, Dutta A, Sathyan K, Guertin M, Sheffield N
Genome Biol . 2021 May; 22(1):155. PMID: 33992117
Nascent RNA profiling is growing in popularity; however, there is no standard analysis pipeline to uniformly process the data and assess quality. Here, we introduce PEPPRO, a comprehensive, scalable workflow...
5.
NOTCH1-driven UBR7 stimulates nucleotide biosynthesis to promote T cell acute lymphoblastic leukemia
Srivastava S, Sahu U, Zhou Y, Hogan A, Sathyan K, Bodner J, et al.
Sci Adv . 2021 Feb; 7(5). PMID: 33571115
Ubiquitin protein ligase E3 component N-recognin 7 (UBR7) is the most divergent member of UBR box-containing E3 ubiquitin ligases/recognins that mediate the proteasomal degradation of its substrates through the N-end...
6.
ARF-AID: A Rapidly Inducible Protein Degradation System That Preserves Basal Endogenous Protein Levels
Sathyan K, Scott T, Guertin M
Curr Protoc Mol Biol . 2020 Aug; 132(1):e124. PMID: 32757370
Inducible degron systems are widely used to specifically and rapidly deplete proteins of interest in cell lines and organisms. An advantage of inducible degradation is that the biological system under...
7.
An improved auxin-inducible degron system preserves native protein levels and enables rapid and specific protein depletion
Sathyan K, McKenna B, Anderson W, Duarte F, Core L, Guertin M
Genes Dev . 2019 Aug; 33(19-20):1441-1455. PMID: 31467088
Rapid perturbation of protein function permits the ability to define primary molecular responses while avoiding downstream cumulative effects of protein dysregulation. The auxin-inducible degron (AID) system was developed as a...