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Mete Civelek

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Articles 114
Citations 6763
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Recent Articles
1.
Harris B, Woo L, Perry R, Wallace A, Civelek M, Wolf M, et al.
Development . 2025 Jan; 152(4). PMID: 39866065
Numerous regulators of cardiomyocyte (CM) proliferation have been identified, yet how they coordinate during cardiac development or regeneration is poorly understood. Here, we developed a computational model of the CM...
2.
Reed J, Hasan F, Karkar A, Banka D, Hinkle J, Shastri P, et al.
iScience . 2024 Dec; 27(12):111323. PMID: 39640571
In humans, dietary patterns impact weight and metabolism differentially across individuals. To uncover genetic determinants for differential dietary effects, we subjected four genetically diverse mouse strains to humanized diets (American,...
3.
Ventresca C, Martschenko D, Wedow R, Civelek M, Tabery J, Carlson J, et al.
Am J Hum Genet . 2024 Sep; 111(10):2107-2116. PMID: 39255798
Same-sex sexual behavior has long interested genetics researchers in part because, while there is evidence of heritability, the trait as typically defined is associated with fewer offspring. Investigations of this...
4.
Rasheed A, Robichaud S, Dennison T, Nguyen M, Geoffrion M, Reed J, et al.
Nat Cardiovasc Res . 2024 Aug; 3(5):594-611. PMID: 39195940
Dysregulation of the hematopoietic niche during hyperlipidemia facilitates pathologic leukocyte production, driving atherogenesis. Although definitive hematopoiesis occurs primarily in the bone marrow, during atherosclerosis this also occurs in the spleen....
5.
Lan T, Palm K, Hoeben L, Diez Benavente E, Perry R, Civelek M, et al.
Atherosclerosis . 2024 Aug; 397:118554. PMID: 39137621
Background And Aims: Tobacco smoking is a known risk factor for atherosclerotic disease, with more elevated risks in women compared to men. We hypothesized that atherosclerotic plaques from smokers show...
6.
Reed J, Huang J, Li Y, Ma L, Banka D, Wabitsch M, et al.
Life Sci Alliance . 2024 May; 7(7. PMID: 38702075
Excess abdominal fat is a sexually dimorphic risk factor for cardio-metabolic disease and is approximated by the waist-to-hip ratio adjusted for body mass index (WHR). Whereas this trait is highly...
7.
Mocci G, Sukhavasi K, Ord T, Bankier S, Singha P, Arasu U, et al.
Circ Res . 2024 Apr; 134(11):1405-1423. PMID: 38639096
Background: While our understanding of the single-cell gene expression patterns underlying the transformation of vascular cell types during the progression of atherosclerosis is rapidly improving, the clinical and pathophysiological relevance...
8.
Diez Benavente E, Hartman R, Sakkers T, Wesseling M, Sloots Y, Slenders L, et al.
Arterioscler Thromb Vasc Biol . 2024 Apr; 44(6):1419-1431. PMID: 38634280
Background: Epigenetic age estimators (clocks) are predictive of human mortality risk. However, it is not yet known whether the epigenetic age of atherosclerotic plaques is predictive for the risk of...
9.
Aherrahrou R, Baig F, Theofilatos K, Lue D, Beele A, Ord T, et al.
Arterioscler Thromb Vasc Biol . 2024 Feb; 44(4):898-914. PMID: 38328934
Background: Smooth muscle cells (SMCs), which make up the medial layer of arteries, are key cell types involved in cardiovascular disease, the leading cause of mortality and morbidity worldwide. In...
10.
Aherrahrou R, Baig F, Theofilatos K, Lue D, Beele A, Ord T, et al.
medRxiv . 2023 Nov; PMID: 37986932
Background: Smooth muscle cells (SMCs), which make up the medial layer of arteries, are key cell types involved in cardiovascular diseases (CVD), the leading cause of mortality and morbidity worldwide....