Michael Holinstat
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Explore the profile of Michael Holinstat including associated specialties, affiliations and a list of published articles.
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101
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2453
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Recent Articles
1.
Rodriguez A, Yu M, Phoo M, Holinstat M, Schwendeman A
Mol Pharm
. 2025 Jan;
22(3):1305-1317.
PMID: 39888835
Platelet activation is a key factor in the development of cardiovascular diseases. High-density lipoprotein (HDL) is known for its cardioprotective activities including antithrombotic actions. While HDL mimetics have been explored...
2.
Kulkarni P, Alluri R, Godwin M, Forbes G, Merkulova A, Lambert S, et al.
Blood
. 2025 Jan;
PMID: 39869832
Antibodies to β2-glycoprotein I (β2GPI) cause thrombosis in antiphospholipid syndrome, however the role of β2GPI in coagulation in vivo is not understood. To address this issue, we developed β2GPI-deficient mice...
3.
Goerger K, Abbott K, Larson M, Holinstat M
J Cardiovasc Dev Dis
. 2025 Jan;
12(1).
PMID: 39852305
Native Americans are disproportionately affected by cardiovascular disease in comparison with other racial and ethnic groups in the United States. Previous research has analyzed risk factors, quantified prevalence rates, and...
4.
Goerger K, Caldwell M, Biermann G, Besh F, Flickema T, Patel P, et al.
Int J Mol Sci
. 2024 Nov;
25(22).
PMID: 39596060
Platelet activation plays an essential role in clot formation to prevent blood loss following vascular damage. In pathologic conditions, platelet activation can lead to obstructive clots, disrupting blood flow and...
5.
Belenkovich M, Veksler R, Kreinin Y, Mekler T, Flores M, Sznitman J, et al.
Micromachines (Basel)
. 2024 Aug;
15(8).
PMID: 39203639
The microvasculature, which makes up the majority of the cardiovascular system, plays a crucial role in the process of thrombosis, with the pathological formation of blood clots inside blood vessels....
6.
Poscablo D, Worthington A, Smith-Berdan S, Rommel M, Manso B, Adili R, et al.
Cell
. 2024 May;
187(12):3090-3107.e21.
PMID: 38749423
Platelet dysregulation is drastically increased with advanced age and contributes to making cardiovascular disorders the leading cause of death of elderly humans. Here, we reveal a direct differentiation pathway from...
7.
Griffin M, Dahlgren A, Nagaswami C, Litvinov R, Keeler K, Madenjian C, et al.
J Thromb Haemost
. 2023 Dec;
22(4):1056-1068.
PMID: 38160724
Background: Blood clots are primarily composed of red blood cells (RBCs), platelets/thrombocytes, and fibrin. Despite the similarities observed between mammals and zebrafish, the composition of fish thrombi is not as...
8.
Stanger L, Yamaguchi A, Holinstat M
J Thromb Haemost
. 2023 Nov;
21(12):3317-3328.
PMID: 38000851
Antiplatelet therapy plays a critical role in the prevention and treatment of major cardiovascular diseases triggered by thrombosis. Since the 1900s, significant progress in reducing morbidity and death caused by...
9.
Rickenberg A, Holinstat M
J Thromb Haemost
. 2023 Oct;
21(11):3082-3084.
PMID: 37858525
No abstract available.
10.
Tran M, Stanger L, Narendra S, Holinstat M, Holman T
Arch Biochem Biophys
. 2023 Sep;
747:109742.
PMID: 37696384
Polyunsaturated fatty acids (PUFAs) have been extensively studied for their health benefits because they can be oxidized by lipoxygenases to form bioactive oxylipins. In this study, we investigated the impact...