Benjamin E Tourdot
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Explore the profile of Benjamin E Tourdot including associated specialties, affiliations and a list of published articles.
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22
Citations
604
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Recent Articles
1.
Tamang H, Stringham E, Tourdot B
Curr Protoc
. 2023 Feb;
3(2):e668.
PMID: 36786557
Platelets play a critical role in hemostasis and thrombosis; therefore, in vitro assays that measure platelet reactivity are fundamental tools to gain insight into these physiologic processes, to diagnose platelet...
2.
Yamaguchi A, van Hoorebeke C, Tourdot B, Perry S, Lee G, Rhoads N, et al.
Pharmacol Res Perspect
. 2023 Jan;
11(1):e01056.
PMID: 36708179
The antiplatelet effect of polyunsaturated fatty acids is primarily attributed to its metabolism to bioactive metabolites by oxygenases, such as lipoxygenases (LOX). Platelets have demonstrated the ability to generate 15-LOX-derived...
3.
Lynch D, Stringham E, Zhang B, Balbin-Cuesta G, Curtis B, Palumbo J, et al.
Blood Adv
. 2022 Jun;
6(15):4645-4656.
PMID: 35737875
Immune thrombocytopenia (ITP) is an acquired bleeding disorder characterized by immunoglobulin G (IgG)-mediated platelet destruction. Current therapies primarily focus on reducing antiplatelet antibodies using immunosuppression or increasing platelet production with...
4.
Colling M, Tourdot B, Kanthi Y
Circ Res
. 2021 Jun;
128(12):2017-2036.
PMID: 34110909
The association between inflammation, infection, and venous thrombosis has long been recognized; yet, only in the last decades have we begun to understand the mechanisms through which the immune and...
5.
Perry S, Horn T, Tourdot B, Yamaguchi A, Kalyanaraman C, Conrad W, et al.
Biochemistry
. 2020 Oct;
59(42):4118-4130.
PMID: 33048542
The oxylipins, 5S,12S-dihydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid (5S,12S-diHETE) and 5S,15S-dihydroxy-6E,8Z,11Z,13E-eicosatetraenoic acid (5S,15S-diHETE), have been identified in cell exudates and have chemotactic activity toward eosinophils and neutrophils. Their biosynthesis has been proposed to occur...
6.
Perry S, Kalyanaraman C, Tourdot B, Conrad W, Akinkugbe O, Freedman J, et al.
J Lipid Res
. 2020 May;
61(7):1087-1103.
PMID: 32404334
The two oxylipins 7S,14S-dihydroxydocosahexaenoic acid (diHDHA) and 7S,17S-diHDHA [resolvin D5 (RvD5)] have been found in macrophages and infectious inflammatory exudates and are believed to function as specialized pro-resolving mediators (SPMs)....
7.
Freedman C, Tran A, Tourdot B, Kalyanaraman C, Perry S, Holinstat M, et al.
Biochemistry
. 2020 Apr;
59(19):1832-1844.
PMID: 32324389
Human reticulocyte 15-lipoxygenase-1 (h15-LOX-1 or ALOX15) and platelet 12-lipoxygenase (h12-LOX or ALOX12) catalysis of docosahexaenoic acid (DHA) and the maresin precursor, 14S-hydroperoxy-4Z,7Z,10Z,12E,16Z,19Z-docosahexaenoic acid (14S-HpDHA), were investigated to determine their product...
8.
Yadav V, Chi L, Zhao R, Tourdot B, Yalavarthi S, Jacobs B, et al.
J Clin Invest
. 2019 Apr;
129(7):2872-2877.
PMID: 30990798
Deep vein thrombosis (DVT), caused by alterations in venous homeostasis is the third most common cause of cardiovascular mortality; however, key molecular determinants in venous thrombosis have not been fully...
9.
Green A, Freedman C, Tena J, Tourdot B, Liu B, Holinstat M, et al.
Biochemistry
. 2018 Nov;
57(48):6726-6734.
PMID: 30407793
The reaction of 5 S,15 S-dihydroperoxyeicosatetraenoic acid (5,15-diHpETE) with human 5-lipoxygenase (LOX), human platelet 12-LOX, and human reticulocyte 15-LOX-1 was investigated to determine the reactivity and relative rates of producing...
10.
Tourdot B, Stoveken H, Trumbo D, Yeung J, Kanthi Y, Edelstein L, et al.
Arterioscler Thromb Vasc Biol
. 2018 May;
38(7):1632-1643.
PMID: 29748334
Objective: Platelet activation after stimulation of PAR (protease-activated receptor) 4 is heightened in platelets from blacks compared with those from whites. The difference in PAR4 signaling by race is partially...