Michael G Garelick
Overview
Explore the profile of Michael G Garelick including associated specialties, affiliations and a list of published articles.
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10
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815
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Recent Articles
1.
Garelick M, MacKay V, Yanagida A, Academia E, Schreiber K, Ladiges W, et al.
Cell Cycle
. 2013 Jul;
12(15):2493-504.
PMID: 23839034
Reducing activity of the mTORC1/S6K1 pathway has been shown to extend lifespan in both vertebrate and invertebrate models. For instance, both pharmacological inhibition of mTORC1 with the drug rapamycin or...
2.
Luo J, Phan T, Yang Y, Garelick M, Storm D
J Neurosci
. 2013 Apr;
33(15):6460-8.
PMID: 23575844
The cyclic adenosine monophosphate (cAMP), mitogen-activated protein kinase (MAPK), and cAMP response element-binding protein (CREB) transcriptional pathway is required for consolidation of hippocampus-dependent memory. In mice, this pathway undergoes a...
3.
Ramos F, Chen S, Garelick M, Dai D, Liao C, Schreiber K, et al.
Sci Transl Med
. 2012 Jul;
4(144):144ra103.
PMID: 22837538
Mutations in LMNA, the gene that encodes A-type lamins, cause multiple diseases including dystrophies of the skeletal muscle and fat, dilated cardiomyopathy, and progeria-like syndromes (collectively termed laminopathies). Reduced A-type...
4.
Pan Y, Zou J, Wang W, Sakagami H, Garelick M, Abel G, et al.
J Biol Chem
. 2012 May;
287(28):23306-17.
PMID: 22645146
Recent studies have led to the exciting idea that adult-born neurons in the dentate gyrus of the hippocampus may play a role in hippocampus-dependent memory formation. However, signaling mechanisms that...
5.
Zweifel L, Fadok J, Argilli E, Garelick M, Jones G, Dickerson T, et al.
Nat Neurosci
. 2011 Apr;
14(5):620-6.
PMID: 21499253
Generalized anxiety is thought to result, in part, from impairments in contingency awareness during conditioning to cues that predict aversive or fearful outcomes. Dopamine neurons of the ventral midbrain exhibit...
6.
Garelick M, Kennedy B
Exp Gerontol
. 2010 Sep;
46(2-3):155-63.
PMID: 20849946
Signaling by target of rapamycin (mTOR in mammals) has been shown to modulate lifespan in several model organisms ranging from yeast to mice. In mice, reduced mTOR signaling by chronic...
7.
Garelick M, Chan G, DiRocco D, Storm D
J Neurosci
. 2009 Sep;
29(35):10835-42.
PMID: 19726641
Hippocampus-dependent memory requires a cAMP signal that is generated by Ca2+-stimulated adenylyl cyclases (AC1, AC8). Young transgenic mice overexpressing AC1 in the forebrain (AC1+ mice) have enhanced hippocampal long-term potentiation,...
8.
Nudelman A, DiRocco D, Lambert T, Garelick M, Le J, Nathanson N, et al.
Hippocampus
. 2009 Jun;
20(4):492-8.
PMID: 19557767
Activity-dependent changes in gene-expression are believed to underlie the molecular representation of memory. In this study, we report that in vivo activation of neurons rapidly induces the CREB-regulated microRNA miR-132....
9.
Garelick M, Storm D
Proc Natl Acad Sci U S A
. 2005 Jun;
102(26):9091-2.
PMID: 15967979
No abstract available.
10.
Chen X, Garelick M, Wang H, Lil V, Athos J, Storm D
Nat Neurosci
. 2005 Jun;
8(7):925-31.
PMID: 15937483
Memory retrieval is a dynamic aspect of memory formation that can be studied separately from other stages of memory processing. Although several signal transduction pathways including ERK/MAP kinase have been...