Derek P DiRocco
Overview
Explore the profile of Derek P DiRocco including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
16
Citations
1545
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Kramann R, Fleig S, Schneider R, Fabian S, DiRocco D, Maarouf O, et al.
J Clin Invest
. 2015 Jul;
125(8):2935-51.
PMID: 26193634
Chronic kidney disease is characterized by interstitial fibrosis and proliferation of scar-secreting myofibroblasts, ultimately leading to end-stage renal disease. The hedgehog (Hh) pathway transcriptional effectors GLI1 and GLI2 are expressed...
2.
Kramann R, Schneider R, DiRocco D, Machado F, Fleig S, Bondzie P, et al.
Cell Stem Cell
. 2014 Dec;
16(1):51-66.
PMID: 25465115
Mesenchymal stem cells (MSCs) reside in the perivascular niche of many organs, including kidney, lung, liver, and heart, although their roles in these tissues are poorly understood. Here, we demonstrate...
3.
Grgic I, Krautzberger A, Hofmeister A, Lalli M, DiRocco D, Fleig S, et al.
J Am Soc Nephrol
. 2014 Mar;
25(9):1979-90.
PMID: 24652793
Myofibroblasts secrete matrix during chronic injury, and their ablation ameliorates fibrosis. Development of new biomarkers and therapies for CKD will be aided by a detailed analysis of myofibroblast gene expression...
4.
DiRocco D, Bisi J, Roberts P, Strum J, Wong K, Sharpless N, et al.
Am J Physiol Renal Physiol
. 2013 Dec;
306(4):F379-88.
PMID: 24338822
Acute kidney injury (AKI) is common and urgently requires new preventative therapies. Expression of a cyclin-dependent kinase (CDK) inhibitor transgene protects against AKI, suggesting that manipulating the tubular epithelial cell...
5.
Kramann R, DiRocco D, Maarouf O, Humphreys B
Curr Pathobiol Rep
. 2013 Dec;
1(4).
PMID: 24319648
Chronic injury to the kidney causes kidney fibrosis with irreversible loss of functional renal parenchyma and leads to the clinical syndromes of chronic kidney disease (CKD) and end-stage renal disease...
6.
Humphreys B, DiRocco D
Kidney Int
. 2013 Oct;
86(3):481-8.
PMID: 24088959
The kidney is a complex organ with over 30 different cell types, and understanding the lineage relationships between these cells is challenging. During nephrogenesis, a central question is how the...
7.
Kramann R, DiRocco D, Humphreys B
J Pathol
. 2013 Sep;
231(3):273-89.
PMID: 24006178
Fibrosis and scar formation results from chronic progressive injury in virtually every tissue and affects a growing number of people around the world. Myofibroblasts drive fibrosis, and recent work has...
8.
DiRocco D, Kobayashi A, Taketo M, McMahon A, Humphreys B
J Am Soc Nephrol
. 2013 Jun;
24(9):1399-412.
PMID: 23766539
Injury to the adult kidney induces a number of developmental genes thought to regulate repair, including Wnt4. During kidney development, early nephron precursors and medullary stroma both express Wnt4, where...
9.
Humphreys B, Czerniak S, DiRocco D, Hasnain W, Cheema R, Bonventre J
Proc Natl Acad Sci U S A
. 2011 May;
108(22):9226-31.
PMID: 21576461
Recently we have established that the kidney tubular epithelium is repaired by surviving epithelial cells. It is not known, however, whether a population of intratubular adult progenitor cells are responsible...
10.
Garelick M, Chan G, DiRocco D, Storm D
J Neurosci
. 2009 Sep;
29(35):10835-42.
PMID: 19726641
Hippocampus-dependent memory requires a cAMP signal that is generated by Ca2+-stimulated adenylyl cyclases (AC1, AC8). Young transgenic mice overexpressing AC1 in the forebrain (AC1+ mice) have enhanced hippocampal long-term potentiation,...