Michael Fairhead
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Explore the profile of Michael Fairhead including associated specialties, affiliations and a list of published articles.
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33
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899
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Recent Articles
11.
Kidd S, Fowler E, Reinhardt T, Compton T, Mateu N, Newman H, et al.
Chem Sci
. 2021 Jun;
11(39):10792-10801.
PMID: 34094333
Organic synthesis underpins the evolution of weak fragment hits into potent lead compounds. Deficiencies within current screening collections often result in the requirement of significant synthetic investment to enable multidirectional...
12.
Douangamath A, Fearon D, Gehrtz P, Krojer T, Lukacik P, Owen C, et al.
Nat Commun
. 2020 Oct;
11(1):5047.
PMID: 33028810
COVID-19, caused by SARS-CoV-2, lacks effective therapeutics. Additionally, no antiviral drugs or vaccines were developed against the closely related coronavirus, SARS-CoV-1 or MERS-CoV, despite previous zoonotic outbreaks. To identify starting...
13.
Tareque R, Hassell-Hart S, Krojer T, Bradley A, Velupillai S, Talon R, et al.
ChemMedChem
. 2020 Aug;
15(24):2513-2520.
PMID: 32812371
Combined photochemical arylation, "nuisance effect" (S Ar) reaction sequences have been employed in the design of small arrays for immediate deployment in medium-throughput X-ray protein-ligand structure determination. Reactions were deliberately...
14.
Krndija D, Fairhead M
Biochem J
. 2019 Nov;
476(23):3583-3593.
PMID: 31738383
Filopodia are thin, actin-based membrane protrusions with roles in sensing external mechanical and chemical cues, such as growth factor gradients in tissues. It was proposed that the chemical sensing role...
15.
Resnick E, Bradley A, Gan J, Douangamath A, Krojer T, Sethi R, et al.
J Am Chem Soc
. 2019 May;
141(22):8951-8968.
PMID: 31060360
Covalent probes can display unmatched potency, selectivity, and duration of action; however, their discovery is challenging. In principle, fragments that can irreversibly bind their target can overcome the low affinity...
16.
Bradley A, Echalier A, Fairhead M, Strain-Damerell C, Brennan P, Bullock A, et al.
Essays Biochem
. 2017 Nov;
61(5):495-503.
PMID: 29118096
The ongoing explosion in genomics data has long since outpaced the capacity of conventional biochemical methodology to verify the large number of hypotheses that emerge from the analysis of such...
17.
Jacobsen M, Fairhead M, Fogelstrand P, Howarth M
Cell Chem Biol
. 2017 Aug;
24(8):1040-1047.e4.
PMID: 28757182
Chemical modification of proteins provides great opportunities to control and visualize living systems. The most common way to modify proteins is reaction of their abundant amines with N-hydroxysuccinimide (NHS) esters....
18.
Dubacheva G, Araya-Callis C, Volbeda A, Fairhead M, Codee J, Howarth M, et al.
J Am Chem Soc
. 2017 Feb;
139(11):4157-4167.
PMID: 28234007
Although multivalent binding to surfaces is an important tool in nanotechnology, quantitative information about the residual valency and orientation of surface-bound molecules is missing. To address these questions, we study...
19.
Fairhead M, Howarth M
Methods Mol Biol
. 2015 Jan;
1266:171-84.
PMID: 25560075
The binding between biotin and streptavidin or avidin is one of the strongest known non-covalent biological interactions. The (strept)avidin-biotin interaction has been widely used for decades in biological research and...
20.
Fairhead M, Shen D, Chan L, Lowe E, Donohoe T, Howarth M
Bioorg Med Chem
. 2014 Aug;
22(19):5476-86.
PMID: 25128469
The pathway of ligand dissociation and how binding sites respond to force are not well understood for any macromolecule. Force effects on biological receptors have been studied through simulation or...