Michael E Harris
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Explore the profile of Michael E Harris including associated specialties, affiliations and a list of published articles.
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83
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1291
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Recent Articles
1.
Kalia N, Snell K, Harris M
Nucleic Acids Res
. 2024 Oct;
52(21):13419-13433.
PMID: 39475186
Coronavirus endoribonuclease Nsp15 contributes to the evasion of host innate immunity by suppressing levels of viral dsRNA. Nsp15 cleaves both ssRNA and dsRNA in vitro with a strong preference for...
2.
Huang T, Chamberlain A, Zhu J, Harris M
RSC Chem Biol
. 2024 Jul;
5(7):652-668.
PMID: 38966670
Bacterial ribonuclease P (RNase P) is a tRNA processing endonuclease that occurs primarily as a ribonucleoprotein with a catalytic RNA subunit (P RNA). As one of the first ribozymes discovered,...
3.
Chamberlain A, Harris M
Methods Mol Biol
. 2024 Jun;
2822:431-441.
PMID: 38907933
Stopped-flow fluorescence spectroscopy is a highly sensitive method for measuring rapid enzyme kinetics. A wide range of fluorophores can be employed, and fluorescence and fluorescence polarization can be measured. Thus,...
4.
Chamberlain A, Huynh L, Huang W, Taylor D, Harris M
J Biol Chem
. 2023 Nov;
300(1):105498.
PMID: 38013087
Developing quantitative models of substrate specificity for RNA processing enzymes is a key step toward understanding their biology and guiding applications in biotechnology and biomedicine. Optimally, models to predict relative...
5.
Yoon S, Ollie E, York D, Piccirilli J, Harris M
Biochemistry
. 2023 Jun;
62(13):2079-2092.
PMID: 37294744
Pistol ribozyme (Psr) is a distinct class of small endonucleolytic ribozymes, which are important experimental systems for defining fundamental principles of RNA catalysis and designing valuable tools in biotechnology. High-resolution...
6.
Li N, Dai Q, Weissman B, Harris M, Piccirilli J
Nucleosides Nucleotides Nucleic Acids
. 2023 May;
42(11):930-943.
PMID: 37233721
5'- labeled RNA oligos are important probes to investigate the mechanism of 2'--transphosphorylation reactions. Here we describe a general and efficient synthetic approach to the phosphoramidite derivatives of 5'- labeled...
7.
Huang T, Snell K, Kalia N, Gardezi S, Guo L, Harris M
J Biol Chem
. 2023 May;
299(6):104787.
PMID: 37149147
Understanding the functional properties of severe acute respiratory syndrome coronavirus 2 nonstructural proteins is essential for defining their roles in the viral life cycle, developing improved therapeutics and diagnostics, and...
8.
Xu Y, Harris M, York D, Wong K
J Chem Theory Comput
. 2023 Feb;
19(4):1322-1332.
PMID: 36753428
RNA strand cleavage by 2'-O-transphosphorylation is catalyzed not only by numerous nucleolytic RNA enzymes (ribozymes) but also by hydroxide or hydronium ions. In experiments, both cleavage of the 5'-linked nucleoside...
9.
Weissman B, Ekesan S, Lin H, Gardezi S, Li N, Giese T, et al.
J Am Chem Soc
. 2023 Jan;
145(5):2830-2839.
PMID: 36706353
Ribonucleases and small nucleolytic ribozymes are both able to catalyze RNA strand cleavage through 2'--transphosphorylation, provoking the question of whether protein and RNA enzymes facilitate mechanisms that pass through the...
10.
Zhu J, Huang W, Zhao J, Huynh L, Taylor D, Harris M
Nat Commun
. 2022 Aug;
13(1):5120.
PMID: 36045135
Binding of precursor tRNAs (ptRNAs) by bacterial ribonuclease P (RNase P) involves an encounter complex (ES) that isomerizes to a catalytic conformation (ES*). However, the structures of intermediates and the...