Michael D Burkart
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Explore the profile of Michael D Burkart including associated specialties, affiliations and a list of published articles.
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204
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3293
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Recent Articles
1.
Halloran M, Naumann R, Jaisingh A, Romero N, Burkart M
Angew Chem Int Ed Engl
. 2025 Feb;
:e202421540.
PMID: 39961781
Aromatic diisocyanates, invaluable commodity chemicals for polymer manufacturing, are produced annually on megaton scales from petroleum-derived diamines via phosgenation. Existing routes toward renewable alternatives are sparse and limited by access...
2.
Gupta A, Molino J, Wnuk-Fink K, Bruckbauer A, Tessman M, Kang K, et al.
ACS ES T Eng
. 2025 Jan;
5(1):36-49.
PMID: 39816185
Microalgae offer a compelling platform for the production of commodity products, due to their superior photosynthetic efficiency, adaptability to nonarable lands and nonpotable water, and their capacity to produce a...
3.
Mellor D, Suo Y, Miyada M, Medina Perez G, Burkart M
Biochemistry
. 2024 Dec;
64(2):351-356.
PMID: 39740789
(Mtb) is a leading cause of death, with an escalating global occurrence of drug-resistant infections that are partially attributed to cell wall mycolic acids derived from type II fatty acid...
4.
Heberlig G, La Clair J, Burkart M
Nature
. 2024 Dec;
638(8049):261-269.
PMID: 39663458
Non-ribosomal peptide synthetases are assembly line biosynthetic pathways that are used to produce critical therapeutic drugs and are typically arranged as large multi-domain proteins called megasynthetases. They synthesize polypeptides using...
5.
Williams R, Caspers-Brown A, Michaud J, Stevens N, Meehan M, Sultana C, et al.
Metabolites
. 2024 Nov;
14(11).
PMID: 39590868
Background: Glyoxal has been implicated as a significant contributor to the formation of secondary organic aerosols, which play a key role in our ability to estimate the impact of aerosols...
6.
Miyada M, Choi Y, Rich K, La Clair J, Burkart M
Chem Sci
. 2024 Nov;
15(47):19913-19919.
PMID: 39568935
Carrier protein-dependent synthases are ubiquitous enzymes involved both in primary and secondary metabolism. Biocatalysis within these synthases is governed by key interactions between the carrier protein, substrate, and partner enzymes....
7.
Chambers R, Rajput B, Scofield G, Reindel J, OShea K, Li R, et al.
ACS Appl Polym Mater
. 2024 Oct;
6(20):12528-12537.
PMID: 39479343
Petroleum-based plastic waste plagues the natural environment, but plastics solve many high-performance solutions across industries. For example, porous polymer membranes are used for air filtration, advanced textiles, energy, and biomedical...
8.
Hoogerland L, van den Berg S, Suo Y, Moriuchi Y, Zoumaro-Djayoon A, Geurken E, et al.
Nat Commun
. 2024 Oct;
15(1):9386.
PMID: 39477942
All free-living microorganisms homeostatically maintain the fluidity of their membranes by adapting lipid composition to environmental temperatures. Here, we quantify enzymes and metabolic intermediates of the Escherichia coli fatty acid...
9.
Jiang Z, Chen J, Mohamed O, Huynh J, Chen A, Tripathi A, et al.
J Am Chem Soc
. 2024 Jul;
146(29):20370-20378.
PMID: 38981108
The antibiotic cerulenin is a fungal natural product identified as a covalent inhibitor of ketosynthases within fatty acid and polyketide biosynthesis. Due to its selective and potent inhibitory activity, cerulenin...
10.
Miyada M, Choi Y, Stepanauskas R, Woyke T, La Clair J, Burkart M
ACS Chem Biol
. 2024 Jun;
19(7):1416-1425.
PMID: 38909314
Carrier proteins (CPs) play a fundamental role in the biosynthesis of fatty acids, polyketides, and non-ribosomal peptides, encompassing many medicinally and pharmacologically relevant compounds. Current approaches to analyze novel carrier-protein-dependent...