Michael D Burkart
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Explore the profile of Michael D Burkart including associated specialties, affiliations and a list of published articles.
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3293
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Recent Articles
11.
Kalaj B, La Clair J, Shen Y, Schwieters C, Deshmukh L, Burkart M
J Am Chem Soc
. 2024 Jun;
146(27):18650-18660.
PMID: 38875499
The acyl carrier protein of , termed AcpP, is a prototypical example of type II fatty acid synthase systems found in many bacteria. It serves as a central hub by...
12.
Allemann M, Tessman M, Reindel J, Scofield G, Evans P, Pomeroy R, et al.
Sci Rep
. 2024 Mar;
14(1):6036.
PMID: 38472254
The accumulation of microplastics in various ecosystems has now been well documented and recent evidence suggests detrimental effects on various biological processes due to this pollution. Accumulation of microplastics in...
13.
Chen A, Re R, Davis T, Tran K, Moriuchi Y, Wu S, et al.
J Am Chem Soc
. 2024 Jan;
146(2):1388-1395.
PMID: 38176024
Site-specific covalent conjugation offers a powerful tool to identify and understand protein-protein interactions. In this study, we discover that sulfur fluoride exchange (SuFEx) warheads effectively crosslink the acyl carrier protein...
14.
Suo Y, Chen A, La Clair J, Burkart M
Biochemistry
. 2023 Dec;
62(24):3548-3553.
PMID: 38039071
Outside of their involvement in energy production, mitochondria play a critical role for the cell through their access to a discrete pathway for fatty acid biosynthesis. Despite decades of study...
15.
Jiang Z, Chen A, Chen J, Sekhon A, Louie G, Noel J, et al.
Chem Sci
. 2023 Oct;
14(39):10925-10933.
PMID: 37829009
Protein-reactive natural products such as the fungal metabolite cerulenin are recognized for their value as therapeutic candidates, due to their ability to selectively react with catalytic residues within a protein...
16.
Sztain T, Corpuz J, Bartholow T, Sanlley Hernandez J, Jiang Z, Mellor D, et al.
ACS Chem Biol
. 2023 Sep;
18(9):2014-2022.
PMID: 37671411
Carrier-protein-dependent metabolic pathways biosynthesize fatty acids, polyketides, and non-ribosomal peptides, producing metabolites with important pharmaceutical, environmental, and industrial properties. Recent findings demonstrate that these pathways rely on selective communication mechanisms...
17.
Dzunkova M, La Clair J, Tyml T, Doud D, Schulz F, Piquer-Esteban S, et al.
Microbiome
. 2023 Jun;
11(1):130.
PMID: 37312139
Background: Nudibranchs comprise a group of > 6000 marine soft-bodied mollusk species known to use secondary metabolites (natural products) for chemical defense. The full diversity of these metabolites and whether...
18.
Chan W, Trieger K, La Clair J, Jamieson C, Burkart M
J Med Chem
. 2023 May;
66(10):6577-6590.
PMID: 37155693
Highly functionalized skeletons of macrolide natural products gain access to rare spatial arrangements of atoms, where changes in stereochemistry can have a profound impact on the structure and function. Spliceosome...
19.
Cao W, Mao H, McCallum N, Zhou X, Sun H, Sharpe C, et al.
Chem Sci
. 2023 Apr;
14(15):4183-4192.
PMID: 37063797
Herein, we investigate synthetic routes to a close mimic of natural pheomelanin. Three different oxidative polymerization routes were attempted to generate synthetic pheomelanin, each giving rise to structurally dissimilar materials....
20.
van der Werf I, Mondala P, Steel S, Balaian L, Ladel L, Mason C, et al.
Cell Rep Med
. 2023 Mar;
4(3):100962.
PMID: 36889320
Pediatric acute myeloid leukemia (pAML) is typified by high relapse rates and a relative paucity of somatic DNA mutations. Although seminal studies show that splicing factor mutations and mis-splicing fuel...