Michael D Bridges
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Explore the profile of Michael D Bridges including associated specialties, affiliations and a list of published articles.
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14
Citations
219
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Recent Articles
1.
Chen M, Kalai T, Cascio D, Bridges M, Whitelegge J, Elgeti M, et al.
Appl Magn Reson
. 2024 Feb;
55(1-3):251-277.
PMID: 38357006
Supplementary Information: The online version contains supplementary material available at 10.1007/s00723-023-01618-8.
2.
Parthasarathy D, Pothula K, Dam K, Ratnapriya S, Cervera Benet H, Parsons R, et al.
bioRxiv
. 2023 Sep;
PMID: 37745449
HIV-1 envelope glycoproteins (Envs) mediate viral entry and are the sole target of neutralizing antibodies. Envs of most primary HIV-1 strains exist in a closed conformation and occasionally sample more...
3.
Muhammednazaar S, Yao J, Necelis M, Park Y, Shen Z, Bridges M, et al.
bioRxiv
. 2023 Jul;
PMID: 37398072
Although membrane proteins fold and function in a lipid bilayer constituting cell membranes, their structure and functionality can be recapitulated in diverse amphiphilic assemblies whose compositions deviate from native membranes....
4.
Yang Z, Dam K, Bridges M, Hoffmann M, DeLaitsch A, Gristick H, et al.
Nat Commun
. 2022 Feb;
13(1):732.
PMID: 35136084
Broadly-neutralizing antibodies (bNAbs) against HIV-1 Env can protect from infection. We characterize Ab1303 and Ab1573, heterologously-neutralizing CD4-binding site (CD4bs) antibodies, isolated from sequentially-immunized macaques. Ab1303/Ab1573 binding is observed only when...
5.
Gaffney K, Guo R, Bridges M, Muhammednazaar S, Chen D, Kim M, et al.
Proc Natl Acad Sci U S A
. 2021 Dec;
119(1).
PMID: 34969836
Defining the denatured state ensemble (DSE) and disordered proteins is essential to understanding folding, chaperone action, degradation, and translocation. As compared with water-soluble proteins, the DSE of membrane proteins is...
6.
Gu X, Bridges M, Yan Y, de Waal P, Zhou X, Suino-Powell K, et al.
J Biol Chem
. 2018 Sep;
293(44):16994-17007.
PMID: 30206123
AMP-activated protein kinase (AMPK) is a master regulator of energy homeostasis and a promising drug target for managing metabolic diseases such as type 2 diabetes. Many pharmacological AMPK activators, and...
7.
Stadtmueller B, Bridges M, Dam K, Lerch M, Huey-Tubman K, Hubbell W, et al.
Immunity
. 2018 Aug;
49(2):235-246.e4.
PMID: 30076100
HIV-1 Envelope (Env) mediates viral-host membrane fusion after binding host-receptor CD4 and coreceptor. Soluble envelopes (SOSIPs), designed to mimic prefusion conformational states of virion-bound envelopes, are proposed immunogens for eliciting...
8.
Yang Z, Bridges M, Lopez C, Rogozhnikova O, Trukhin D, Brooks E, et al.
J Magn Reson
. 2016 May;
269:50-54.
PMID: 27214582
Site-directed spin labeling (SDSL) in combination with electron paramagnetic resonance (EPR) spectroscopy has become an important tool for measuring distances in proteins on the order of a few nm. For...
9.
Chui A, Lopez C, Brooks E, Chua K, Doupey T, Foltz G, et al.
Biochemistry
. 2015 Feb;
54(9):1717-28.
PMID: 25715079
The intrinsically disordered protein (IDP) stathmin plays an important regulatory role in cytoskeletal maintenance through its helical binding to tubulin and microtubules. However, it lacks a stable fold in the...
10.
Yang Z, Jimenez-Oses G, Lopez C, Bridges M, Houk K, Hubbell W
J Am Chem Soc
. 2014 Oct;
136(43):15356-65.
PMID: 25290172
Site-directed spin labeling in combination with EPR is a powerful method for providing distances on the nm scale in biological systems. The most popular strategy, double electron-electron resonance (DEER), is...