Duilio Cascio
Overview
Explore the profile of Duilio Cascio including associated specialties, affiliations and a list of published articles.
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Articles
144
Citations
6800
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Recent Articles
1.
Vlahakis N, Qu S, Richards L, Moraes L, Cascio D, Nelson H, et al.
Acta Crystallogr C Struct Chem
. 2025 Feb;
81(Pt 3):116-130.
PMID: 39982366
Electron counting helped realize the resolution revolution in single-particle cryoEM and is now accelerating the determination of MicroED structures. Its advantages are best demonstrated by new direct electron detectors capable...
2.
Mahoney B, Lyman L, Ford J, Soule J, Cheung N, Goring A, et al.
Proc Natl Acad Sci U S A
. 2024 Dec;
122(1):e2411833122.
PMID: 39739808
To successfully mount infections, nearly all bacterial pathogens must acquire iron, a key metal cofactor that primarily resides within human hemoglobin. causes the life-threatening respiratory disease diphtheria and captures hemoglobin...
3.
Agdanowski M, Castells-Graells R, Sawaya M, Cascio D, Yeates T, Arbing M
Acta Crystallogr F Struct Biol Commun
. 2024 May;
80(Pt 5):107-115.
PMID: 38767964
Imaging scaffolds composed of designed protein cages fused to designed ankyrin repeat proteins (DARPins) have enabled the structure determination of small proteins by cryogenic electron microscopy (cryo-EM). One particularly well...
4.
Miller J, Agdanowski M, Dolinsky J, Sawaya M, Cascio D, Rodriguez J, et al.
Acta Crystallogr D Struct Biol
. 2024 Mar;
80(Pt 4):270-278.
PMID: 38451205
Macromolecular crystallography generally requires the recovery of missing phase information from diffraction data to reconstruct an electron-density map of the crystallized molecule. Most recent structures have been solved using molecular...
5.
Chen M, Kalai T, Cascio D, Bridges M, Whitelegge J, Elgeti M, et al.
Appl Magn Reson
. 2024 Feb;
55(1-3):251-277.
PMID: 38357006
Supplementary Information: The online version contains supplementary material available at 10.1007/s00723-023-01618-8.
6.
Lu J, Ge P, Sawaya M, Hughes M, Boyer D, Cao Q, et al.
J Biol Chem
. 2023 Dec;
300(2):105531.
PMID: 38072051
Heterogeneous nuclear ribonucleoprotein A2 (hnRNPA2) is a human ribonucleoprotein that transports RNA to designated locations for translation via its ability to phase separate. Its mutated form, D290V, is implicated in...
7.
Abskharon R, Pan H, Sawaya M, Seidler P, Olivares E, Chen Y, et al.
Proc Natl Acad Sci U S A
. 2023 Oct;
120(41):e2300258120.
PMID: 37801475
Despite much effort, antibody therapies for Alzheimer's disease (AD) have shown limited efficacy. Challenges to the rational design of effective antibodies include the difficulty of achieving specific affinity to critical...
8.
Mahoney B, Goring A, Wang Y, Dasika P, Zhou A, Grossbard E, et al.
J Inorg Biochem
. 2023 Sep;
249:112368.
PMID: 37729854
Heme is the most abundant source of iron in the human body and is actively scavenged by bacterial pathogens during infections. Corynebacterium diphtheriae and other species of actinobacteria scavenge heme...
9.
Castells-Graells R, Meador K, Arbing M, Sawaya M, Gee M, Cascio D, et al.
Proc Natl Acad Sci U S A
. 2023 Sep;
120(37):e2305494120.
PMID: 37669364
Cryoelectron microscopy (Cryo-EM) has enabled structural determination of proteins larger than about 50 kDa, including many intractable by any other method, but it has largely failed for smaller proteins. Here,...
10.
Tayeb-Fligelman E, Bowler J, Tai C, Sawaya M, Jiang Y, Garcia Jr G, et al.
Nat Commun
. 2023 May;
14(1):2379.
PMID: 37185252
The self-assembly of the Nucleocapsid protein (NCAP) of SARS-CoV-2 is crucial for its function. Computational analysis of the amino acid sequence of NCAP reveals low-complexity domains (LCDs) akin to LCDs...