Wayne L Hubbell
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Explore the profile of Wayne L Hubbell including associated specialties, affiliations and a list of published articles.
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113
Citations
5091
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Recent Articles
1.
Grosskopf J, Sidabras J, Altenbach C, Anderson J, Mett R, Strangeway R, et al.
Protein Sci
. 2024 Nov;
33(12):e5220.
PMID: 39565088
Site-directed spin labeling electron paramagnetic resonance (SDSL-EPR) using nitroxide spin labels is a well-established technology for mapping site-specific secondary and tertiary structure and for monitoring conformational changes in proteins of...
2.
Grosskopf J, Sidabras J, Altenbach C, Anderson J, Mett R, Strangeway R, et al.
bioRxiv
. 2024 May;
PMID: 38766191
Site-directed spin labeling electron paramagnetic resonance (SDSL-EPR) using nitroxide spin labels is a well-established technology for mapping site-specific secondary and tertiary structure and for monitoring conformational changes in proteins of...
3.
Zhao J, Elgeti M, OBrien E, Sar C, Ei Daibani A, Heng J, et al.
Nature
. 2024 Apr;
629(8011):474-480.
PMID: 38600384
The µ-opioid receptor (µOR) is an important target for pain management and molecular understanding of drug action on µOR will facilitate the development of better therapeutics. Here we show, using...
4.
Chen M, Kalai T, Cascio D, Bridges M, Whitelegge J, Elgeti M, et al.
Appl Magn Reson
. 2024 Feb;
55(1-3):251-277.
PMID: 38357006
Supplementary Information: The online version contains supplementary material available at 10.1007/s00723-023-01618-8.
5.
Khan F, Elgeti M, Grandfield S, Paz A, Naughton F, Marcoline F, et al.
Nat Commun
. 2023 Nov;
14(1):7511.
PMID: 37980423
Sodium-dependent glucose transporters (SGLTs) couple a downhill Na ion gradient to actively transport sugars. Here, we investigate the impact of the membrane potential on vSGLT structure and function using sugar...
6.
Parthasarathy D, Pothula K, Dam K, Ratnapriya S, Cervera Benet H, Parsons R, et al.
bioRxiv
. 2023 Sep;
PMID: 37745449
HIV-1 envelope glycoproteins (Envs) mediate viral entry and are the sole target of neutralizing antibodies. Envs of most primary HIV-1 strains exist in a closed conformation and occasionally sample more...
7.
Muhammednazaar S, Yao J, Necelis M, Park Y, Shen Z, Bridges M, et al.
bioRxiv
. 2023 Jul;
PMID: 37398072
Although membrane proteins fold and function in a lipid bilayer constituting cell membranes, their structure and functionality can be recapitulated in diverse amphiphilic assemblies whose compositions deviate from native membranes....
8.
Zhao J, Elgeti M, OBrien E, Sar C, Ei Daibani A, Heng J, et al.
bioRxiv
. 2023 May;
PMID: 37163120
The μ-opioid receptor (μOR) is an important target for pain management and the molecular understanding of drug action will facilitate the development of better therapeutics. Here we show, using double...
9.
Yang Z, Dam K, Bridges M, Hoffmann M, DeLaitsch A, Gristick H, et al.
Nat Commun
. 2022 Feb;
13(1):732.
PMID: 35136084
Broadly-neutralizing antibodies (bNAbs) against HIV-1 Env can protect from infection. We characterize Ab1303 and Ab1573, heterologously-neutralizing CD4-binding site (CD4bs) antibodies, isolated from sequentially-immunized macaques. Ab1303/Ab1573 binding is observed only when...
10.
Gaffney K, Guo R, Bridges M, Muhammednazaar S, Chen D, Kim M, et al.
Proc Natl Acad Sci U S A
. 2021 Dec;
119(1).
PMID: 34969836
Defining the denatured state ensemble (DSE) and disordered proteins is essential to understanding folding, chaperone action, degradation, and translocation. As compared with water-soluble proteins, the DSE of membrane proteins is...