Michael B Wheeler
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Explore the profile of Michael B Wheeler including associated specialties, affiliations and a list of published articles.
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Articles
127
Citations
4487
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Recent Articles
21.
Al Rijjal D, Liu Y, Lai M, Song Y, Danaei Z, Wu A, et al.
iScience
. 2021 Aug;
24(8):102909.
PMID: 34458694
Omega-3 fatty acid prescription drugs, Vascepa (≥96% eicosapentaenoic acid [EPA] ethyl ester) and Lovaza (46.5% EPA and 37.5% docosahexaenoic acid ethyl ester) are known therapeutic regimens to treat hypertriglyceridemia. However,...
22.
Bastin G, Luu L, Batchuluun B, Mighiu A, Beadman S, Zhang H, et al.
Biomedicines
. 2021 Aug;
9(8).
PMID: 34440212
A number of diverse G-protein signaling pathways have been shown to regulate insulin secretion from pancreatic β-cells. Accordingly, regulator of G-protein signaling (RGS) proteins have also been implicated in coordinating...
23.
Glavas M, Hui Q, Miao I, Yang F, Erener S, Prentice K, et al.
Sci Rep
. 2021 Jul;
11(1):14032.
PMID: 34234216
Overconsumption of saturated fats promotes obesity and type 2 diabetes. Excess weight gain in early life may be particularly detrimental by promoting earlier diabetes onset and potentially by adversely affecting...
24.
Xu J, Wijesekara N, Regeenes R, Al Rijjal D, Piro A, Song Y, et al.
JCI Insight
. 2021 May;
6(10).
PMID: 34027899
GWAS have shown that the common R325W variant of SLC30A8 (ZnT8) increases the risk of type 2 diabetes (T2D). However, ZnT8 haploinsufficiency is protective against T2D in humans, counterintuitive to...
25.
Khan S, Al Rijjal D, Piro A, Wheeler M
Drug Discov Today
. 2021 Jan;
26(4):982-992.
PMID: 33476566
AI integration in plant-based traditional medicine could be used to overcome drug discovery challenges.
26.
Khan S, Manialawy Y, Obersterescu A, Cox B, Gunderson E, Wheeler M
iScience
. 2020 Oct;
23(10):101566.
PMID: 33103069
Gestational diabetes mellitus (GDM) is the top risk factor for future type 2 diabetes (T2D) development. Ethnicity profoundly influences who will transition from GDM to T2D, with high risk observed...
27.
Song E, Da Eira D, Jani S, Sepa-Kishi D, Vu V, Hunter H, et al.
Diabetes
. 2020 Oct;
70(1):51-61.
PMID: 33046483
Increased myocardial autophagy has been established as an important stress-induced cardioprotective response. Three weeks after generating cardiomyocyte-specific autophagy deficiency, via inducible deletion of autophagy-related protein 7 (Atg7), we found that...
28.
Lai M, Al Rijjal D, Rost H, Dai F, Gunderson E, Wheeler M
Elife
. 2020 Aug;
9.
PMID: 32748787
Approximately, 35% of women with Gestational Diabetes (GDM) progress to Type 2 Diabetes (T2D) within 10 years. However, links between GDM and T2D are not well understood. We used a...
29.
Untereiner A, Xu J, Bhattacharjee A, Cabrera O, Hu C, Dai F, et al.
Diabetes Obes Metab
. 2020 Jun;
22(11):2021-2031.
PMID: 32558194
Aim: To examine the mechanism of action of γ-aminobutyric acid (GABA) on β-cell proliferation and investigate if co-treatment with Ly49, a novel GABA type A receptor positive allosteric modulator (GABA...
30.
Manialawy Y, Khan S, Bhattacharjee A, Wheeler M
J Biol Chem
. 2020 May;
295(29):9879-9892.
PMID: 32439805
Type 2 diabetes is a chronic metabolic disease characterized by pancreatic β-cell dysfunction and peripheral insulin resistance. Among individuals with type 2 diabetes, ∼30% exhibit hypomagnesemia. Hypomagnesemia has been linked...