Michael A Brehm
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Explore the profile of Michael A Brehm including associated specialties, affiliations and a list of published articles.
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119
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5147
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Recent Articles
1.
Kumar A, Goel H, Wisniewski C, Wang T, Geng Y, Wang M, et al.
J Clin Invest
. 2024 Oct;
134(22).
PMID: 39352757
The high rate of recurrence after radiation therapy in triple-negative breast cancer (TNBC) indicates that novel approaches and targets are needed to enhance radiosensitivity. Here, we report that neuropilin-2 (NRP2),...
2.
Sari G, Dhatchinamoorthy K, Orellano-Ariza L, Ferreira L, Brehm M, Rock K
Res Sq
. 2024 Sep;
PMID: 39281881
Background: In order for cancers to progress, they must evade elimination by CD8 T cells or other immune mechanisms. CD8 T cells recognize and kill tumor cells that display immunogenic...
3.
Novobrantseva T, Manfra D, Ritter J, Razlog M, ONuallain B, Zafari M, et al.
Cancers (Basel)
. 2024 Aug;
16(16).
PMID: 39199551
Omnipresent suppressive myeloid populations in the tumor microenvironment limit the efficacy of T-cell-directed immunotherapies, become more inhibitory after administration of T-cell checkpoint inhibitors, and are overall associated with worse survival...
4.
OConnor K, Kishimoto K, Kuzma I, Wagner K, Selway J, Roderick J, et al.
Leukemia
. 2024 Mar;
38(5):951-962.
PMID: 38553571
Relapse in T-cell acute lymphoblastic leukemia (T-ALL) may signify the persistence of leukemia-initiating cells (L-ICs). Ectopic TAL1/LMO expression defines the largest subset of T-ALL, but its role in leukemic transformation...
5.
Stepien T, Singletary L, Guerra F, Karlinsey J, Libby S, Jaslow S, et al.
mBio
. 2024 Mar;
15(4):e0045424.
PMID: 38497655
Importance: Salmonella enterica is a common cause of gastrointestinal infections worldwide. The serovars Typhi and Paratyphi A cause a distinctive systemic illness called enteric fever, whose pathogenesis is incompletely understood....
6.
Daman K, Yan J, Burzenski L, Kady J, Shultz L, Brehm M, et al.
bioRxiv
. 2023 Nov;
PMID: 38014123
Background: Facioscapulohumeral muscular dystrophy (FSHD) disease progression is associated with muscle inflammation, although its role in FSHD muscle pathology is unknown. Methods: We have developed a novel humanized mouse strain,...
7.
Mukhopadhyay D, Goel H, Xiong C, Goel S, Kumar A, Li R, et al.
Cell Rep
. 2023 Nov;
42(11):113347.
PMID: 37910503
Understanding the cell biological mechanisms that enable tumor cells to persist after therapy is necessary to improve the treatment of recurrent disease. Here, we demonstrate that transient receptor potential channel...
8.
Kearns N, Lobo M, Genga R, Abramowitz R, Parsi K, Min J, et al.
Dev Cell
. 2023 Sep;
58(18):1801-1818.e15.
PMID: 37751684
Approaches to study human pharyngeal foregut endoderm-a developmental intermediate that is linked to various human syndromes involving pharynx development and organogenesis of tissues such as thymus, parathyroid, and thyroid-have been...
9.
Nayyar N, de Sauvage M, Chuprin J, Sullivan E, Singh M, Torrini C, et al.
Clin Cancer Res
. 2023 Aug;
30(2):420-435.
PMID: 37611074
Purpose: Brain metastases are associated with high morbidity and are often resistant to immune checkpoint inhibitors. We evaluated whether CDK4/6 inhibitor (CDKi) abemaciclib can sensitize intracranial tumors to programmed cell...
10.
Harmon C, Zaborowski A, Moore H, St Louis P, Slattery K, Duquette D, et al.
Nat Cancer
. 2023 Jul;
4(8):1122-1137.
PMID: 37474835
γδ T cells are important tissue-resident, innate T cells that are critical for tissue homeostasis. γδ cells are associated with positive prognosis in most tumors; however, little is known about...