Micael R Cunha
Overview
Explore the profile of Micael R Cunha including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
8
Citations
30
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Cunha M, Do Amaral B, Takarada J, Valderrama G, Batista A, Batista Jr J, et al.
Chembiochem
. 2024 Jun;
25(22):e202400506.
PMID: 38923811
Autophagic flux plays a crucial role in various diseases. Recently, the lysosomal ion channel TRPML1 has emerged as a promising target in lysosomal storage diseases, such as mucolipidosis. The discovery...
2.
de Souza Gama F, Dutra L, Hawgood M, Dos Reis C, Serafim R, Ferreira Jr M, et al.
J Med Chem
. 2024 May;
67(11):8609-8629.
PMID: 38780468
Vaccinia-related kinase 1 (VRK1) and the δ and ε isoforms of casein kinase 1 (CK1) are linked to various disease-relevant pathways. However, the lack of tool compounds for these kinases...
3.
Takarada J, Cunha M, Almeida V, Vasconcelos S, Santiago A, Godoi P, et al.
Bioorg Med Chem
. 2023 Dec;
98:117561.
PMID: 38157838
The dual-specificity protein kinase MKK3 has been implicated in tumor cell proliferation and survival, yet its precise role in cancer remains inconclusive. A critical step in elucidating the kinase's involvement...
4.
Cunha M, Catta-Preta C, Takarada J, Moreira G, Massirer K, Counago R
J Biol Chem
. 2023 May;
299(6):104807.
PMID: 37172730
Here, we report a bioluminescence resonance energy transfer (BRET) assay as a novel way to investigate the binding of unlabeled ligands to the human transient receptor potential mucolipin 1 (hTRPML1),...
5.
Segretti N, Takarada J, Ferreira Jr M, Da Silva Santiago A, Teodoro B, Damiao M, et al.
Bioorg Med Chem Lett
. 2022 May;
68:128764.
PMID: 35504513
The discovery of potent and selective inhibitors for understudied kinases can provide relevant pharmacological tools to illuminate their biological functions. DYRK1A and DYRK1B are protein kinases linked to chronic human...
6.
Bhardwaj R, Lindinger S, Neuberger A, Nadezhdin K, Singh A, Cunha M, et al.
Sci Adv
. 2020 Nov;
6(48).
PMID: 33246965
Epithelial calcium channel TRPV6 plays vital roles in calcium homeostasis, and its dysregulation is implicated in multifactorial diseases, including cancers. Here, we study the molecular mechanism of selective nanomolar-affinity TRPV6...
7.
Cunha M, Bhardwaj R, Lindinger S, Butorac C, Romanin C, Hediger M, et al.
ACS Med Chem Lett
. 2019 Sep;
10(9):1341-1345.
PMID: 31531207
Herein we report the first photoswitchable inhibitor of Transient Receptor Potential Vanilloid 6 (TRPV6), a selective calcium channel involved in a number of diseases and in cancer progression. By surveying...
8.
Fernandes T, Cunha M, Sakata R, Candido T, Baby A, Tavares M, et al.
Arch Pharm (Weinheim)
. 2017 Sep;
350(11).
PMID: 28940630
Alzheimer's disease (AD) is the most common type of dementia and related to the degeneration of hippocampal cholinergic neurons, which dramatically affects cognitive ability. Acetylcholinesterase (AChE) inhibitors are employed as...