Matthias A Hediger
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Explore the profile of Matthias A Hediger including associated specialties, affiliations and a list of published articles.
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115
Citations
4188
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Recent Articles
1.
Lee S, Weiss T, Buhler M, Mena J, Lottenbach Z, Wegmann R, et al.
Nat Med
. 2024 Sep;
30(11):3196-3208.
PMID: 39304781
Glioblastoma, the most aggressive primary brain cancer, has a dismal prognosis, yet systemic treatment is limited to DNA-alkylating chemotherapies. New therapeutic strategies may emerge from exploring neurodevelopmental and neurophysiological vulnerabilities...
2.
Pujol-Gimenez J, Baumann S, Ho T, Augustynek B, Hediger M
Biomolecules
. 2024 Jul;
14(7).
PMID: 39062485
The peptide/histidine transporter PHT1 () is expressed in the lysosomal membranes of immune cells where it plays an important role in metabolic and inflammatory signaling. PHT1 is an H-coupled/histidine symporter...
3.
Zaugg J, Pujol Gimenez J, Cabra R, Hofstetter W, Hediger M, Albrecht C
Chimia (Aarau)
. 2023 Dec;
76(12):996-1004.
PMID: 38069794
The TransCure project entitled 'Iron Transporters DMT1 and FPN1' took an interdisciplinary approach combining structural biology, chemistry and physiology to gain new insights into iron transport. Proteins studied included Divalent...
4.
Tscherrig D, Bhardwaj R, Biner D, Dernic J, Ross-Kaschitza D, Peinelt C, et al.
Cell Calcium
. 2023 Nov;
117:102834.
PMID: 38006628
Many physiological functions, such as cell differentiation, proliferation, muscle contraction, neurotransmission and fertilisation, are regulated by changes of Ca levels. The major Ca store in cells is the endoplasmic reticulum...
5.
Radvanyi Z, Yoo E, Kandasamy P, Salas-Bastos A, Monnerat S, Refardt J, et al.
J Biol Chem
. 2023 Nov;
300(1):105480.
PMID: 37992803
The bone-derived hormone fibroblast growth factor-23 (FGF23) has recently received much attention due to its association with chronic kidney disease and cardiovascular disease progression. Extracellular sodium concentration ([Na]) plays a...
6.
Nydegger D, Pujol-Gimenez J, Kandasamy P, Vogt B, Hediger M
Viruses
. 2023 Jul;
15(7).
PMID: 37515120
As the COVID-19 pandemic progresses, new variants of SARS-CoV-2 continue to emerge. This underscores the need to develop optimized tools to study such variants, along with new coronaviruses that may...
7.
Schlosser P, Scherer N, Grundner-Culemann F, Monteiro-Martins S, Haug S, Steinbrenner I, et al.
Nat Genet
. 2023 Jun;
55(6):995-1008.
PMID: 37277652
The kidneys operate at the interface of plasma and urine by clearing molecular waste products while retaining valuable solutes. Genetic studies of paired plasma and urine metabolomes may identify underlying...
8.
Pujol-Gimenez J, Mirzaa G, Blue E, Albano G, Miller D, Allworth A, et al.
Ann Clin Transl Neurol
. 2023 May;
10(6):1046-1053.
PMID: 37194416
SLC1A4 is a trimeric neutral amino acid transporter essential for shuttling L-serine from astrocytes into neurons. Individuals with biallelic variants in SLC1A4 are known to have spastic tetraplegia, thin corpus...
9.
Gyimesi G, Hediger M
Molecules
. 2023 Feb;
28(3).
PMID: 36770817
Transmembrane transport of small organic and inorganic molecules is one of the cornerstones of cellular metabolism. Among transmembrane transporters, solute carrier (SLC) proteins form the largest, albeit very diverse, superfamily...
10.
Sanchez-Collado J, Nieto-Felipe J, Jardin I, Bhardwaj R, Berna-Erro A, Salido G, et al.
Cancers (Basel)
. 2023 Jan;
15(1).
PMID: 36612199
N-linked glycosylation is a post-translational modification that affects protein function, structure, and interaction with other proteins. The store-operated Ca entry (SOCE) core proteins, Orai1 and STIM1, exhibit N-glycosylation consensus motifs....