Menno Hoekstra
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Explore the profile of Menno Hoekstra including associated specialties, affiliations and a list of published articles.
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Articles
119
Citations
2223
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Recent Articles
1.
de Korte D, Hoekstra M
Biomolecules
. 2025 Feb;
15(2).
PMID: 40001488
Protein arginine methyltransferase 1 (PRMT1) is the main PRMT family member involved in the formation of monomethylarginine and asymmetric dimethylarginine on its protein substrates. Many protein substrates of PRMT1 are...
2.
de Jong L, Harpal C, van den Berg D, Hoekstra M, Peter N, Rissmann R, et al.
Drug Metab Dispos
. 2024 Sep;
52(12):1429-1437.
PMID: 39349298
Compromised hepatic drug metabolism in response to proinflammatory cytokine release is primarily attributed to downregulation of cytochrome P450 (CYP) enzymes. However, whether inflammation also affects other phase I and phase...
3.
4.
Hoekstra M, de Jong L, van der Geest R, de Leeuw L, Krisnamurthi R, Geerling J, et al.
Biomolecules
. 2024 Apr;
14(4).
PMID: 38672446
Preclinical studies regarding the potential of liver X receptor (LXR) agonists to inhibit macrophage foam cell formation and the development of atherosclerotic lesions are generally executed in mice fed with...
5.
Hoekstra M, Snip O, Janusz P, Bernabe Kleijn M, Truitt 3rd E, Sullivan B, et al.
J Physiol
. 2024 Apr;
602(9):1939-1951.
PMID: 38606903
Recombinant human proteoglycan 4 (rhPRG4) is a macromolecular mucin-like glycoprotein that is classically studied as a lubricant within eyes and joints. Given that endogenously produced PRG4 is present within atherosclerotic...
6.
Hoekstra M, Van Eck M
Curr Atheroscler Rep
. 2024 Mar;
26(5):139-146.
PMID: 38498115
Purpose Of Review: Here, we summarize the key findings from preclinical studies that tested the concept that editing of hepatic genes can lower plasma low-density lipoprotein (LDL)-cholesterol levels to subsequently...
7.
Hoekstra M, Zhang Z, Lindenburg P, Van Eck M
J Lipid Atheroscler
. 2024 Feb;
13(1):69-79.
PMID: 38299166
Objective: Scavenger receptor class B type I (SR-BI) is primarily known for its role in the selective uptake of cholesteryl esters (CEs) from high-density lipoproteins (HDLs). Here we investigated whether...
8.
Kraaijenhof J, Tromp T, Nurmohamed N, Reeskamp L, Langenkamp M, Levels J, et al.
J Am Heart Assoc
. 2023 Oct;
12(21):e030476.
PMID: 37889183
Background ANGPTL3 (angiopoietin-like protein 3) is an acknowledged crucial regulator of lipid metabolism by virtue of its inhibitory effect on lipoprotein lipase and endothelial lipase. It is currently unknown whether...
9.
van der Sluis R, van den Aardweg T, Sijsenaar T, Van Eck M, Hoekstra M
Biomolecules
. 2023 Sep;
13(9).
PMID: 37759687
The steroid 11beta-hydroxylase inhibitor metyrapone is able to effectively reverse the hypercortisolemia detected in human Cushing's Syndrome patients. In this current preclinical study, we investigated whether metyrapone monotherapy can also...
10.
Hoekstra M, Van Eck M
Atheroscler Plus
. 2023 Sep;
53:33-41.
PMID: 37663008
Background And Aims: Non-alcoholic fatty liver disease (NAFLD), a high incidence liver pathology, is associated with a ∼1.5-fold higher cardiovascular disease risk. This phenomenon is generally attributed to the NAFLD-associated...