J Kar Kruijt
Overview
Explore the profile of J Kar Kruijt including associated specialties, affiliations and a list of published articles.
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Articles
14
Citations
513
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0
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Recent Articles
1.
Li Z, Kruijt J, van der Sluis R, Van Berkel T, Hoekstra M
Physiol Genomics
. 2013 Jan;
45(7):268-75.
PMID: 23362145
The liver consists of different cell types that together synchronize crucial roles in liver homeostasis. Since nuclear receptors constitute an important class of drug targets that are involved in a...
2.
Zhao Y, Pennings M, Vrins C, Calpe-Berdiel L, Hoekstra M, Kruijt J, et al.
Atherosclerosis
. 2011 Aug;
218(2):314-22.
PMID: 21840001
High-density lipoprotein (HDL) mediated reverse cholesterol transport (RCT) is regarded to be crucial for prevention of foam cell formation and atherosclerosis. ABC-transporter A1 (ABCA1) and scavenger receptor BI (SR-BI) are...
3.
Hildebrand R, Lammers B, Meurs I, Korporaal S, de Haan W, Zhao Y, et al.
Arterioscler Thromb Vasc Biol
. 2010 May;
30(7):1439-45.
PMID: 20431066
Objective: Disruption of scavenger receptor class B type I (SR-BI) in mice impairs high-density lipoprotein (HDL)-cholesterol (HDL-C) delivery to the liver and induces susceptibility to atherosclerosis. In this study, it...
4.
Hoekstra M, Li Z, Kruijt J, Van Eck M, Van Berkel T, Kuiper J
J Hepatol
. 2009 Dec;
52(2):244-51.
PMID: 20015565
Background & Aims: Recent studies have suggested that variations in PNPLA3 are associated with non-alcoholic fatty liver disease (NAFLD). To gain insight into the potential function of PNPLA3 in liver,...
5.
Hoekstra M, Meurs I, Koenders M, Out R, Hildebrand R, Kruijt J, et al.
J Lipid Res
. 2008 Jan;
49(4):738-45.
PMID: 18204096
Receptor-mediated cholesterol uptake has been suggested to play a role in maintaining the adrenal intracellular free cholesterol pool and the ability to produce hormones. Therefore, in the current study, we...
6.
Van Eck M, Hoekstra M, Out R, Bos I, Kruijt J, Hildebrand R, et al.
J Lipid Res
. 2007 Oct;
49(1):136-46.
PMID: 17954936
Scavenger receptor class B type I (SR-BI) functions as an HDL receptor that promotes the selective uptake of cholesteryl esters (CEs). The physiological role of SR-BI in VLDL metabolism, however,...
7.
Ye D, Hoekstra M, Out R, Meurs I, Kruijt J, Hildebrand R, et al.
Atherosclerosis
. 2007 Aug;
196(2):650-8.
PMID: 17727861
Background: ABC-transporters play an important role in lipid trafficking. Therefore, hepatic expression patterns of ABC-transporters involved in the regulation of cholesterol metabolism were evaluated. Methods And Results: RT-PCR analysis showed...
8.
Van Eck M, Hoekstra M, Hildebrand R, Yaong Y, Stengel D, Kruijt J, et al.
Arterioscler Thromb Vasc Biol
. 2007 Aug;
27(11):2413-9.
PMID: 17717299
Objective: In the current study the effect of disruption of SR-BI, a prominent regulator of HDL metabolism, on the activity of the HDL-associated antioxidant enzymes PON1 and PAF-AH as well...
9.
Van Eck M, Ye D, Hildebrand R, Kruijt J, de Haan W, Hoekstra M, et al.
Circ Res
. 2007 Feb;
100(5):678-85.
PMID: 17293475
Abundant amounts of cholesteryl ester transfer protein (CETP) are found in macrophage-derived foam cells in the arterial wall, but its function in atherogenesis is unknown. To investigate the role of...
10.
Hoekstra M, Stitzinger M, van Wanrooij E, Michon I, Kruijt J, Kamphorst J, et al.
J Lipid Res
. 2006 Aug;
47(10):2198-207.
PMID: 16885566
Liver parenchymal cells play a dominant role in hepatic metabolism and thereby total body cholesterol homeostasis. To gain insight into the specific pathways and genes involved in the response of...