Melissa S Harris
Overview
Explore the profile of Melissa S Harris including associated specialties, affiliations and a list of published articles.
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19
Citations
937
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Recent Articles
1.
Calabrese M, Rajamohan F, Harris M, Caspers N, Magyar R, Withka J, et al.
Structure
. 2014 Jul;
22(8):1161-1172.
PMID: 25066137
AMP-activated protein kinase (AMPK) is a principal metabolic regulator affecting growth and response to cellular stress. Comprised of catalytic and regulatory subunits, each present in multiple forms, AMPK is best...
2.
Activation of AMP-activated protein kinase revealed by hydrogen/deuterium exchange mass spectrometry
Landgraf R, Goswami D, Rajamohan F, Harris M, Calabrese M, Hoth L, et al.
Structure
. 2013 Oct;
21(11):1942-53.
PMID: 24076403
AMP-activated protein kinase (AMPK) monitors cellular energy, regulates genes involved in ATP synthesis and consumption, and is allosterically activated by nucleotides and synthetic ligands. Analysis of the intact enzyme with...
3.
Shamblen S, Harris M, Ringwalt C, Flewelling R, Clark H, Hanley S
Subst Use Misuse
. 2011 Feb;
46(8):1049-59.
PMID: 21345047
Introduction: Recent national youth surveys suggest that alcohol availability plays a role in determining use. One measure of availability receiving recent attention is outlet density; however, few studies have examined...
4.
Vincus A, Ringwalt C, Harris M, Shamblen S
J Drug Educ
. 2010 Nov;
40(1):37-49.
PMID: 21038762
We present the short-term results of a quasi-experimental evaluation of the revised D.A.R.E. (Drug Abuse Resistance Education) curriculum. Study outcomes examined were D.A.R.E.'s effects on three substances, namely students' lifetime...
5.
Wang Z, Watt W, Brooks N, Harris M, Urban J, Boatman D, et al.
Biochim Biophys Acta
. 2010 Jun;
1804(9):1817-31.
PMID: 20580860
Because of their central role in programmed cell death, the caspases are attractive targets for developing new therapeutics against cancer and autoimmunity, myocardial infarction and ischemic damage, and neurodegenerative diseases....
6.
Anderson C, Harris M, Kovarik R, Skelton J
Int Q Community Health Educ
. 2010 Jun;
30(2):115-40.
PMID: 20570801
Research shows expectant mothers with oral infections may have an increased risk for delivering preterm, low birth weight babies. Difficulty accessing dental services, limited resources, and beliefs about dental care...
7.
Rajamohan F, Harris M, Frisbie R, Hoth L, Geoghegan K, Valentine J, et al.
Protein Expr Purif
. 2010 May;
73(2):189-97.
PMID: 20451617
AMP-activated protein kinase (AMPK) is an energy-sensing serine/threonine protein kinase that plays a central role in whole-body energy homeostasis. AMPK is a heterotrimeric enzyme with a catalytic (alpha) subunit and...
8.
Hall T, Emmons T, Chrencik J, Gormley J, Weinberg R, Leone J, et al.
Protein Expr Purif
. 2009 Sep;
69(1):54-63.
PMID: 19781647
Janus-associated kinases (JAKs) play critical roles in cytokine signaling, and have emerged as viable therapeutic targets in inflammation and oncology related diseases. To date, targeting JAK proteins with highly selective...
9.
Sarver R, Bills E, Bolton G, Bratton L, Caspers N, Dunbar J, et al.
J Med Chem
. 2008 Jun;
51(13):3804-13.
PMID: 18540668
Clinical studies have demonstrated that statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) inhibitors, are effective at lowering mortality levels associated with cardiovascular disease; however, 2-7% of patients may experience statin-induced myalgia...
10.
Pfefferkorn J, Choi C, Larsen S, Auerbach B, Hutchings R, Park W, et al.
J Med Chem
. 2007 Dec;
51(1):31-45.
PMID: 18072721
In light of accumulating evidence that aggressive LDL-lowering therapy may offer increased protection against coronary heart disease, we undertook the design and synthesis of a novel series of HMG-CoA reductase...