Graeme Bainbridge
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Explore the profile of Graeme Bainbridge including associated specialties, affiliations and a list of published articles.
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10
Citations
202
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Recent Articles
1.
Nambulli S, Rennick L, Acciardo A, Tilston-Lunel N, Ho G, Crossland N, et al.
Proc Natl Acad Sci U S A
. 2022 Oct;
119(43):e2209405119.
PMID: 36251995
Feline morbillivirus (FeMV) is a recently discovered pathogen of domestic cats and has been classified as a morbillivirus in the family. We determined the complete sequence of FeMV directly from...
2.
Gow D, Sauter K, Pridans C, Moffat L, Sehgal A, Stutchfield B, et al.
Mol Ther
. 2014 Jun;
22(9):1580-92.
PMID: 24962162
We have produced an Fc conjugate of colony-stimulating factor (CSF) 1 with an improved circulating half-life. CSF1-Fc retained its macrophage growth-promoting activity, and did not induce proinflammatory cytokines in vitro....
3.
Strietzel C, Bergeron L, Oliphant T, Mutchler V, Choromanski L, Bainbridge G
Vet Immunol Immunopathol
. 2014 Feb;
158(3-4):214-23.
PMID: 24560097
Very little is known about the functional properties of feline IgGs. Here we report the in vitro characterization of cloned feline IgGs. Rapid amplification of cDNA ends (RACE) and full-length...
4.
Steiniger S, Dunkle W, Bammert G, Wilson T, Krishnan A, Dunham S, et al.
Mol Immunol
. 2014 Feb;
59(1):71-8.
PMID: 24509215
Complementarity determining regions (CDR) are responsible for binding antigen and provide substantial diversity to the antibody repertoire, with VH CDR3 of the immunoglobulin variable heavy (VH) domain playing a dominant...
5.
Bergeron L, McCandless E, Dunham S, Dunkle B, Zhu Y, Shelly J, et al.
Vet Immunol Immunopathol
. 2013 Nov;
157(1-2):31-41.
PMID: 24268690
To date, very little is known about the functional characteristics of the four published canine IgG subclasses. It is not clear how each subclass engages the immune system via complement-dependent...
6.
Sarver R, Bills E, Bolton G, Bratton L, Caspers N, Dunbar J, et al.
J Med Chem
. 2008 Jun;
51(13):3804-13.
PMID: 18540668
Clinical studies have demonstrated that statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) inhibitors, are effective at lowering mortality levels associated with cardiovascular disease; however, 2-7% of patients may experience statin-induced myalgia...
7.
Pfefferkorn J, Choi C, Larsen S, Auerbach B, Hutchings R, Park W, et al.
J Med Chem
. 2007 Dec;
51(1):31-45.
PMID: 18072721
In light of accumulating evidence that aggressive LDL-lowering therapy may offer increased protection against coronary heart disease, we undertook the design and synthesis of a novel series of HMG-CoA reductase...
8.
Pfefferkorn J, Song Y, Sun K, Miller S, Trivedi B, Choi C, et al.
Bioorg Med Chem Lett
. 2007 Jun;
17(16):4538-44.
PMID: 17574412
This manuscript describes the design and synthesis of a series of pyrrole-based inhibitors of HMG-CoA reductase for the treatment of hypercholesterolemia. Analogs were optimized using structure-based design and physical property...
9.
Pfefferkorn J, Choi C, Song Y, Trivedi B, Larsen S, Askew V, et al.
Bioorg Med Chem Lett
. 2007 Jun;
17(16):4531-7.
PMID: 17574411
Using structure-based design, a novel series of conformationally restricted, pyrrole-based inhibitors of HMG-CoA reductase were discovered. Leading analogs demonstrated potent inhibition of cholesterol synthesis in both in vitro and in...
10.
Bilder P, Lightle S, Bainbridge G, Ohren J, Finzel B, Sun F, et al.
Biochemistry
. 2006 Feb;
45(6):1712-22.
PMID: 16460018
Acetyl-coA carboxylase (ACC) is a central metabolic enzyme that catalyzes the committed step in fatty acid biosynthesis: biotin-dependent conversion of acetyl-coA to malonyl-coA. The bacterial carboxyltransferase (CT) subunit of ACC...