Meghan E Turnis
Overview
Explore the profile of Meghan E Turnis including associated specialties, affiliations and a list of published articles.
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15
Citations
1740
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Recent Articles
1.
Wright T, Turnis M, Grace C, Li X, Brakefield L, Wang Y, et al.
Mol Cell
. 2024 Mar;
84(7):1338-1353.e8.
PMID: 38503284
MCL-1 is essential for promoting the survival of many normal cell lineages and confers survival and chemoresistance in cancer. Beyond apoptosis regulation, MCL-1 has been linked to modulating mitochondrial metabolism,...
2.
Rockfield S, Turnis M, Rodriguez-Enriquez R, Bathina M, Ng S, Kurtz N, et al.
Life Sci Alliance
. 2024 Mar;
7(6).
PMID: 38467404
The mitochondrial contact site and cristae organizing system (MICOS) is important for crista junction formation and for maintaining inner mitochondrial membrane architecture. A key component of the MICOS complex is...
3.
Turnis M, Kaminska E, Smith K, Kartchner B, Vogel P, Laxton J, et al.
Blood
. 2021 Jan;
137(14):1945-1958.
PMID: 33512417
Although BCL-xL is critical to the survival of mature erythrocytes, it is still unclear whether other antiapoptotic molecules mediate survival during earlier stages of erythropoiesis. Here, we demonstrate that erythroid-specific...
4.
Smith K, Budhraja A, Lynch J, Roberts K, Panetta J, Connelly J, et al.
Mol Cancer Res
. 2020 Dec;
19(4):636-650.
PMID: 33288732
Antiapoptotic is one of the most frequently amplified genes in human cancers and elevated expression confers resistance to many therapeutics including the BH3-mimetic agents ABT-199 and ABT-263. The antimalarial, dihydroartemisinin...
5.
Cunha L, Yang M, Carter R, Guy C, Harris L, Crawford J, et al.
Cell
. 2018 Sep;
175(2):429-441.e16.
PMID: 30245008
Targeting autophagy in cancer cells and in the tumor microenvironment are current goals of cancer therapy. However, components of canonical autophagy play roles in other biological processes, adding complexity to...
6.
Budhraja A, Turnis M, Churchman M, Kothari A, Yang X, Xu H, et al.
Clin Cancer Res
. 2017 Oct;
23(24):7558-7568.
PMID: 28974549
BCR-ABL B-ALL leukemic cells are highly dependent on the expression of endogenous antiapoptotic MCL-1 to promote viability and are resistant to BH3-mimetic agents such as navitoclax (ABT-263) that target BCL-2,...
7.
Turnis M, Sawant D, Szymczak-Workman A, Andrews L, Delgoffe G, Yano H, et al.
Immunity
. 2016 Feb;
44(2):316-29.
PMID: 26872697
Regulatory T (Treg) cells pose a major barrier to effective anti-tumor immunity. Although Treg cell depletion enhances tumor rejection, the ensuing autoimmune sequelae limits its utility in the clinic and...
8.
Turnis M, Andrews L, Vignali D
Eur J Immunol
. 2015 May;
45(7):1892-905.
PMID: 26018646
Inhibitory receptors expressed on T cells control immune responses while limiting autoimmunity. However, tumors can hijack these "checkpoints" for protection from immune attack. Tumor-specific T cells that exhibit an exhausted,...
9.
Shi L, Kalupahana N, Turnis M, Neale G, Hock H, Vignali D, et al.
Proc Natl Acad Sci U S A
. 2013 Aug;
110(34):E3198-205.
PMID: 23918371
Foxp3(+) regulatory T (T(reg)) cells are essential for the maintenance of self-tolerance and immune homeostasis. The majority of T(reg) cells is generated in the thymus as a specific subset of...
10.
Delgoffe G, Woo S, Turnis M, Gravano D, Guy C, Overacre A, et al.
Nature
. 2013 Aug;
501(7466):252-6.
PMID: 23913274
Regulatory T cells (Treg cells) have a crucial role in the immune system by preventing autoimmunity, limiting immunopathology, and maintaining immune homeostasis. However, they also represent a major barrier to...