Matthias Preller
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Explore the profile of Matthias Preller including associated specialties, affiliations and a list of published articles.
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34
Citations
569
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Recent Articles
11.
Manstein D, Preller M
Adv Exp Med Biol
. 2020 May;
1239:61-84.
PMID: 32451856
Several small molecule effectors of myosin function that target the motor domains of myosin classes I, II, V, and VI have been identified. Four distinct binding sites in the myosin...
12.
Osmanovic A, Widjaja M, Forster A, Weder J, Wattjes M, Lange I, et al.
J Neurol
. 2020 May;
267(9):2732-2743.
PMID: 32447552
Amyotrophic lateral sclerosis (ALS) and hereditary spastic paraplegia (HSP) are motor neuron diseases sharing clinical, pathological, and genetic similarities. While biallelic SPG7 mutations are known to cause recessively inherited HSP,...
13.
Viswanathan M, Schmidt W, Franz P, Rynkiewicz M, Newhard C, Madan A, et al.
Nat Commun
. 2020 May;
11(1):2417.
PMID: 32415060
Striated muscle contraction is regulated by the translocation of troponin-tropomyosin strands over the thin filament surface. Relaxation relies partly on highly-favorable, conformation-dependent electrostatic contacts between actin and tropomyosin, which position...
14.
Shcherbakova A, Preller M, Taft M, Pujols J, Ventura S, Tiemann B, et al.
Elife
. 2019 Dec;
8.
PMID: 31868591
Previous studies demonstrated importance of C-mannosylation for efficient protein secretion. To study its impact on protein folding and stability, we analyzed both C-mannosylated and non-C-mannosylated thrombospondin type 1 repeats (TSRs)...
15.
Ehlert J, Kronemann J, Zumbragel N, Preller M
Molecules
. 2019 Nov;
24(23).
PMID: 31771200
Lipases are among the most frequently used biocatalysts in organic synthesis, allowing numerous environmentally friendly and inexpensive chemical transformations. Here, we present a biomimetic strategy based on iron(III)-catalyzed oxidative coupling...
16.
In vivo efficacy of mutant IDH1 inhibitor HMS-101 and structural resolution of distinct binding site
Chaturvedi A, Goparaju R, Gupta C, Weder J, Klunemann T, Araujo Cruz M, et al.
Leukemia
. 2019 Oct;
34(2):416-426.
PMID: 31586149
Mutations in isocitrate dehydrogenase 1 (IDH1) are found in 6% of AML patients. Mutant IDH produces R-2-hydroxyglutarate (R-2HG), which induces histone- and DNA-hypermethylation through the inhibition of epigenetic regulators, thus...
17.
Schadzek P, Stahl Y, Preller M, Ngezahayo A
FEBS Open Bio
. 2019 Apr;
9(5):840-850.
PMID: 31034164
Connexins (Cx) are proteins that form cell-to-cell gap junction channels. A mutation at position 188 in the second extracellular loop (E2) domain of hCx46 has been linked to an autosomal...
18.
Chinthalapudi K, Heissler S, Preller M, Sellers J, Manstein D
Elife
. 2017 Dec;
6.
PMID: 29256864
Despite a generic, highly conserved motor domain, ATP turnover kinetics and their activation by F-actin vary greatly between myosin-2 isoforms. Here, we present a 2.25 Å pre-powerstroke state (ADP⋅VO) crystal...
19.
Mohammadi-Ostad-Kalayeh S, Hrupins V, Helmsen S, Ahlbrecht C, Stahl F, Scheper T, et al.
Bioorg Med Chem
. 2017 Oct;
25(24):6345-6352.
PMID: 29042222
A facile method for testing ATP binding in a highly miniaturized microarray environment using human HSP70 and DnaK from Mycobacterium tuberculosis as biological targets is reported. Supported by molecular modelling...
20.
Beyer U, Brand F, Martens H, Weder J, Christians A, Elyan N, et al.
Acta Neuropathol
. 2017 Oct;
134(6):905-922.
PMID: 29030706
In search of novel germline alterations predisposing to tumors, in particular to gliomas, we studied a family with two brothers affected by anaplastic gliomas, and their father and paternal great-uncle...