Wiebke Ewert
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Explore the profile of Wiebke Ewert including associated specialties, affiliations and a list of published articles.
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Articles
13
Citations
225
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Recent Articles
1.
Ewert W, Bartens C, Ongouta J, Holmes M, Heutling A, Kishore A, et al.
Nat Commun
. 2025 Mar;
16(1):2464.
PMID: 40075103
Amide synthases catalyze the formation of macrolactam rings from aniline-containing polyketide-derived seco-acids as found in the important class of ansamycin antibiotics. One of these amide synthases is the geldanamycin amide...
2.
Kyriazi D, Voth L, Bader A, Ewert W, Gerlach J, Elfrink K, et al.
Nat Commun
. 2024 Nov;
15(1):9947.
PMID: 39550360
Aberrant Ras homologous (Rho) GTPase signalling is a major driver of cancer metastasis, and GTPase-activating proteins (GAPs), the negative regulators of RhoGTPases, are considered promising targets for suppressing metastasis, yet...
3.
Reinke P, Schubert R, Oberthur D, Galchenkova M, Rahmani Mashhour A, Gunther S, et al.
Nat Commun
. 2024 May;
15(1):3827.
PMID: 38714735
The main protease (M) of SARS-CoV-2 is critical for viral function and a key drug target. M is only active when reduced; turnover ceases upon oxidation but is restored by...
4.
Falke S, Lieske J, Herrmann A, Loboda J, Karnicar K, Gunther S, et al.
J Med Chem
. 2024 Apr;
67(9):7048-7067.
PMID: 38630165
Emerging RNA viruses, including SARS-CoV-2, continue to be a major threat. Cell entry of SARS-CoV-2 particles via the endosomal pathway involves cysteine cathepsins. Due to ubiquitous expression, cathepsin L (CatL)...
5.
Reinke P, de Souza E, Gunther S, Falke S, Lieske J, Ewert W, et al.
Commun Biol
. 2023 Oct;
6(1):1058.
PMID: 37853179
Several drug screening campaigns identified Calpeptin as a drug candidate against SARS-CoV-2. Initially reported to target the viral main protease (M), its moderate activity in M inhibition assays hints at...
6.
Franz P, Ewert W, Preller M, Tsiavaliaris G
Int J Mol Sci
. 2022 Oct;
23(19).
PMID: 36233360
The author wishes to make the following correction to this paper [...].
7.
Srinivasan V, Brognaro H, Prabhu P, de Souza E, Gunther S, Reinke P, et al.
Commun Biol
. 2022 Aug;
5(1):805.
PMID: 35953531
SARS-CoV-2 papain-like protease (PLpro) covers multiple functions. Beside the cysteine-protease activity, facilitating cleavage of the viral polypeptide chain, PLpro has the additional and vital function of removing ubiquitin and ISG15...
8.
Ewert W, Gunther S, Miglioli F, Falke S, Reinke P, Niebling S, et al.
Front Chem
. 2022 Apr;
10:832431.
PMID: 35480391
The papain-like protease (PLpro) of SARS-CoV-2 is essential for viral propagation and, additionally, dysregulation of the host innate immune system. Using a library of 40 potential metal-chelating compounds we performed...
9.
Forster A, Brand F, Banan R, Huneburg R, Weber C, Ewert W, et al.
Acta Neuropathol
. 2021 Apr;
142(1):191-210.
PMID: 33929593
The genetic basis of brain tumor development is poorly understood. Here, leukocyte DNA of 21 patients from 15 families with ≥ 2 glioma cases each was analyzed by whole-genome or...
10.
Gunther S, Reinke P, Fernandez-Garcia Y, Lieske J, Lane T, Ginn H, et al.
Science
. 2021 Apr;
372(6542):642-646.
PMID: 33811162
The coronavirus disease (COVID-19) caused by SARS-CoV-2 is creating tremendous human suffering. To date, no effective drug is available to directly treat the disease. In a search for a drug...