Matthias Negri
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Explore the profile of Matthias Negri including associated specialties, affiliations and a list of published articles.
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Citations
305
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Recent Articles
1.
Sager C, Weber S, Negri M, Banachowicz P, Moller G, Adamski J, et al.
J Steroid Biochem Mol Biol
. 2020 Nov;
206:105790.
PMID: 33246154
17β-Hydroxysteroid dehydrogenase type 2 (17β-HSD2) catalyzes the conversion of highly active estrogens and androgens into their less active forms using NAD as cofactor. Substrate and cofactor specificities of 17β-HSD2 have...
2.
Weidel E, Negri M, Empting M, Hinsberger S, Hartmann R
Future Med Chem
. 2014 Dec;
6(18):2057-72.
PMID: 25531968
Aims: In order to identify new scaffolds for drug discovery, surface plasmon resonance is frequently used to screen structurally diverse libraries. Usually, hit rates are low and identification processes are...
3.
Hutter M, Brengel C, Negri M, Henn C, Zimmer C, Hartmann R, et al.
J Mol Model
. 2014 May;
20(6):2255.
PMID: 24842325
PqsD mediates the conversion of anthraniloyl-coenzyme A (ACoA) to 2-heptyl-4-hydroxyquinoline (HHQ), a precursor of the Pseudomonas quinolone signal (PQS) molecule. Due to the role of the quinolone signaling pathway of...
4.
Hinsberger S, Husecken K, Groh M, Negri M, Haupenthal J, Hartmann R
J Med Chem
. 2013 Oct;
56(21):8332-8.
PMID: 24112046
The bacterial RNA polymerase (RNAP) is a validated target for broad spectrum antibiotics. However, the efficiency of drugs is reduced by resistance. To discover novel RNAP inhibitors, a pharmacophore based...
5.
Steinbach A, Maurer C, Weidel E, Henn C, Brengel C, Hartmann R, et al.
BMC Biophys
. 2013 Aug;
6(1):10.
PMID: 23916145
Background: PQS (PseudomonasQuinolone Signal) and its precursor HHQ are signal molecules of the P. aeruginosa quorum sensing system. They explicate their role in mammalian pathogenicity by binding to the receptor...
6.
Weidel E, de Jong J, Brengel C, Storz M, Braunshausen A, Negri M, et al.
J Med Chem
. 2013 Jul;
56(15):6146-55.
PMID: 23834469
Pseudomonas aeruginosa employs a characteristic pqs quorum sensing (QS) system that functions via the signal molecules PQS and its precursor HHQ. They control the production of a number of virulence...
7.
Sahner J, Groh M, Negri M, Haupenthal J, Hartmann R
Eur J Med Chem
. 2013 May;
65:223-31.
PMID: 23711833
Rising resistance against current antibiotics necessitates the development of antibacterial agents with alternative targets. The "switch region" of RNA polymerase (RNAP), addressed by the myxopyronins, could be such a novel...
8.
Gobbi S, Hu Q, Negri M, Zimmer C, Belluti F, Rampa A, et al.
J Med Chem
. 2013 Feb;
56(4):1723-9.
PMID: 23363058
Imidazolylmethylflavones previously reported by us as aromatase inhibitors proved to be able to interact with aldosterone synthase (CYP11B2), a cytochrome P450 enzyme involved in the biosynthesis of the mineralcorticoid hormone...
9.
Husecken K, Negri M, Fruth M, Boettcher S, Hartmann R, Haupenthal J
ACS Chem Biol
. 2013 Jan;
8(4):758-66.
PMID: 23330640
The number of bacterial strains that are resistant against antibiotics increased dramatically during the past decades. This fact stresses the urgent need for the development of new antibacterial agents with...
10.
Marchais-Oberwinkler S, Xu K, Wetzel M, Perspicace E, Negri M, Meyer A, et al.
J Med Chem
. 2012 Nov;
56(1):167-81.
PMID: 23145773
Inhibition of 17β-HSD2 is an attractive mechanism for the treatment of osteoporosis. We report here the optimization of human 17β-HSD2 inhibitors in the 2,5-thiophene amide class by varying the size...