Matthew Ung
Overview
Explore the profile of Matthew Ung including associated specialties, affiliations and a list of published articles.
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15
Citations
442
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0
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Recent Articles
1.
Zhang J, Lee D, Dhiman V, Jiang P, Xu J, McGillivray P, et al.
Nat Commun
. 2020 Jul;
11(1):3696.
PMID: 32728046
ENCODE comprises thousands of functional genomics datasets, and the encyclopedia covers hundreds of cell types, providing a universal annotation for genome interpretation. However, for particular applications, it may be advantageous...
2.
Ung M, Schaafsma E, Mattox D, Wang G, Cheng C
PeerJ
. 2020 Apr;
8:e8797.
PMID: 32231885
Background: The "dark matter" of the genome harbors several non-coding RNA species including Long non-coding RNAs (lncRNAs), which have been implicated in neoplasia but remain understudied. RNA-seq has provided deep...
3.
Feng W, Wilkins O, Bang S, Ung M, Li J, An J, et al.
Cell Rep
. 2019 Dec;
29(11):3405-3420.e5.
PMID: 31825825
Although it is established that fatty acid (FA) synthesis supports anabolic growth in cancer, the role of exogenous FA uptake remains elusive. Here we show that, during acquisition of resistance...
4.
Shee K, Wells J, Ung M, Hampsch R, Traphagen N, Yang W, et al.
Clin Cancer Res
. 2019 Sep;
26(1):159-170.
PMID: 31558472
Purpose: We hypothesized that integrated analysis of cancer types from different lineages would reveal novel molecularly defined subgroups with unique therapeutic vulnerabilities. On the basis of the molecular similarities between...
5.
Brothers 2nd J, Ung M, Escalante-Chong R, Ross J, Zhang J, Cha Y, et al.
Biochem Pharmacol
. 2018 Mar;
152:84-93.
PMID: 29551586
The tremendous expansion of data analytics and public and private big datasets presents an important opportunity for pre-clinical drug discovery and development. In the field of life sciences, the growth...
6.
Almiron Bonnin D, Ran C, Havrda M, Liu H, Hitoshi Y, Zhang Z, et al.
Mol Cancer Ther
. 2017 Feb;
16(4):705-716.
PMID: 28138037
Despite abundant evidence implicating receptor tyrosine kinases (RTK), including the platelet-derived growth factor receptor (PDGFR), in the pathogenesis of glioblastoma (GBM), the clinical use of RTK inhibitors in this disease...
7.
Cheng C, Andrews E, Yan K, Ung M, Wang D, Gerstein M
Genome Biol
. 2015 Apr;
16:63.
PMID: 25880651
Many biological networks naturally form a hierarchy with a preponderance of downward information flow. In this study, we define a score to quantify the degree of hierarchy in a network...
8.
Balboni A, Cherukuri P, Ung M, DeCastro A, Cheng C, DiRenzo J
Mol Cancer Res
. 2015 Feb;
13(4):732-42.
PMID: 25700283
Unlabelled: The TGFβ superfamily regulates a broad range of cellular processes, including proliferation, cell-fate specification, differentiation, and migration. Molecular mechanisms underlying this high degree of pleiotropy and cell-type specificity are...
9.
Tan J, Ung M, Cheng C, Greene C
Pac Symp Biocomput
. 2015 Jan;
:132-43.
PMID: 25592575
Big data bring new opportunities for methods that efficiently summarize and automatically extract knowledge from such compendia. While both supervised learning algorithms and unsupervised clustering algorithms have been successfully applied...
10.
Canfield K, Li J, Wilkins O, Morrison M, Ung M, Wells W, et al.
Cell Cycle
. 2015 Jan;
14(4):648-55.
PMID: 25590338
Approximately 25% of breast cancers overexpress and depend on the receptor tyrosine kinase ERBB2, one of 4 ERBB family members. Targeted therapies directed against ERBB2 have been developed and used...