Matthew S Lawrence
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Explore the profile of Matthew S Lawrence including associated specialties, affiliations and a list of published articles.
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14
Citations
344
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Recent Articles
1.
Schlosser A, Pilecki B, Allen C, Benest A, Lynch A, Hua J, et al.
Mol Ther
. 2025 Jan;
33(3):1048-1072.
PMID: 39863929
Neovascular age-related macular degeneration and diabetic macular edema are leading causes of vision loss evoked by retinal neovascularization and vascular leakage. The glycoprotein microfibrillar-associated protein 4 (MFAP4) is an integrin...
2.
Lee Q, Chan W, Qu X, Sun Y, Abdelkarim H, Le J, et al.
Cell Rep Med
. 2023 Oct;
4(10):101223.
PMID: 37794584
Wet age-related macular degeneration (AMD), characterized by leaky neovessels emanating from the choroid, is a main cause of blindness. As current treatments for wet AMD require regular intravitreal injections of...
3.
Chern K, Issac K, Gumbs Z, OConnor M, Lawrence M, Lipinski D
Gene Ther
. 2023 May;
30(9):714-722.
PMID: 37221271
While many studies have investigated the use of recombinant adeno-associated vectors (rAAV) in the posterior chamber for treatment of inherited retinal diseases, fewer studies have looked at rAAV's ability to...
4.
OCallaghan J, Delaney C, OConnor M, van Batenburg-Sherwood J, Schicht M, Lutjen-Drecoll E, et al.
Sci Adv
. 2023 Apr;
9(16):eadf6537.
PMID: 37075118
Approximately 80 million people globally are affected by glaucoma, with a projected increase to over 110 million by 2040. Substantial issues surrounding patient compliance remain with topical eye drops, and...
5.
Wakeman D, Weed M, Perez S, Cline E, Viola K, Wilcox K, et al.
Neuropathol Appl Neurobiol
. 2022 Feb;
48(4):e12800.
PMID: 35156715
Aims: An obstacle to developing new treatment strategies for Alzheimer's disease (AD) has been the inadequate translation of findings in current AD transgenic rodent models to the prediction of clinical...
6.
Hudson N, Celkova L, Hopkins A, Greene C, Storti F, Ozaki E, et al.
JCI Insight
. 2019 Aug;
4(15).
PMID: 31391341
Age-related macular degeneration (AMD) is the leading cause of central retinal vision loss worldwide, with an estimated 1 in 10 people over the age of 55 showing early signs of...
7.
Rottiers V, Obad S, Petri A, McGarrah R, Lindholm M, Black J, et al.
Sci Transl Med
. 2013 Nov;
5(212):212ra162.
PMID: 24259050
MicroRNAs (miRNAs) regulate many aspects of human biology. They target mRNAs for translational repression or degradation through base pairing with 3' untranslated regions, primarily via seed sequences (nucleotides 2 to...
8.
Miller B, Zeier Z, Xi L, Lanz T, Deng S, Strathmann J, et al.
Proc Natl Acad Sci U S A
. 2012 Feb;
109(8):3125-30.
PMID: 22315408
Schizophrenia is characterized by affective, cognitive, neuromorphological, and molecular abnormalities that may have a neurodevelopmental origin. MicroRNAs (miRNAs) are small noncoding RNA sequences critical to neurodevelopment and adult neuronal processes...
9.
Glogowski S, Ward K, Lawrence M, Goody R, Proksch J
J Ocul Pharmacol Ther
. 2012 Jan;
28(3):290-8.
PMID: 22235843
Purpose: This investigation evaluated the ocular and systemic pharmacokinetics of besifloxacin in African green monkeys compared with cynomolgus monkeys following topical ocular dosing. Methods: A suspension formulation containing 0.6% besifloxacin...
10.
Goody R, Hu W, Shafiee A, Struharik M, Bartels S, Lopez F, et al.
Exp Eye Res
. 2011 Mar;
92(6):464-72.
PMID: 21414311
We developed and validated a new nonhuman primate model of laser-induced choroidal neovascularization (CNV) that addresses study design limitations prevalent in laser-induced CNV-based efficacy studies. Laser-induced Bruch's membrane disruption triggers...