John D Elsworth
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Explore the profile of John D Elsworth including associated specialties, affiliations and a list of published articles.
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63
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2000
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Recent Articles
1.
Murti A, Wilson C, Pemberton A, Corey T, Dzikiti L, Elsworth J, et al.
Vet Sci
. 2024 Dec;
11(12).
PMID: 39729007
Social housing provides a high level of enrichment for captive non-human primates, but providing this in research situations can be challenging. We have developed a multifactorial animal selection and introduction...
2.
Jamwal S, Blackburn J, Elsworth J
Biol Sex Differ
. 2023 Sep;
14(1):65.
PMID: 37770961
Background: Paraoxonase 2 (PON2) and neuronal uncoupling proteins (UCP4 and UCP5) possess antioxidant, anti-apoptotic activities and minimize accumulation of reactive oxygen species in mitochondria. While age and sex are risk...
3.
Wakeman D, Weed M, Perez S, Cline E, Viola K, Wilcox K, et al.
Neuropathol Appl Neurobiol
. 2022 Feb;
48(4):e12800.
PMID: 35156715
Aims: An obstacle to developing new treatment strategies for Alzheimer's disease (AD) has been the inadequate translation of findings in current AD transgenic rodent models to the prediction of clinical...
4.
Jamwal S, Blackburn J, Elsworth J
Free Radic Biol Med
. 2021 Dec;
178:215-218.
PMID: 34890766
Mitochondrial dysfunction and oxidative stress contribute to the neuropathology of neurodegenerative disorders such as Parkinson's disease (PD). Paraoxonase-2 (PON2) is a mitochondrial protein that mitigates oxidative stress, enhances mitochondrial function...
5.
Blackburn J, Jamwal S, Wang W, Elsworth J
Neurochem Int
. 2021 Nov;
152:105222.
PMID: 34767873
Paraoxonase-2 (PON2) enhances mitochondria function and protects against oxidative stress. Stimulating its expression has therapeutic potential for diseases where oxidative stress plays a significant role in the pathology, such as...
6.
Jamwal S, Blackburn J, Elsworth J
Free Radic Biol Med
. 2021 Mar;
167:201-204.
PMID: 33722626
The development of several neurodegenerative disorders, such as Parkinson's disease, has been linked with decreased mitochondrial performance, leading to oxidative stress as a result of increased production of reactive oxygen...
7.
Jamwal S, Blackburn J, Elsworth J
Pharmacol Ther
. 2020 Oct;
219:107705.
PMID: 33039420
Neurodegenerative diseases represent some of the most devastating neurological disorders, characterized by progressive loss of the structure and function of neurons. Current therapy for neurodegenerative disorders is limited to symptomatic...
8.
Jamwal S, Elsworth J, Rahi V, Kumar P
Expert Rev Neurother
. 2020 Jul;
20(11):1123-1141.
PMID: 32720531
Introduction: Modulation of gene expression using gene therapy as well as modulation of immune activation using immunotherapy has attracted considerable attention as rapidly emerging potential therapeutic intervention for the treatment...
9.
Chung Y, Seay M, Elsworth J, Redmond D
Stem Cells Dev
. 2020 Jul;
29(19):1294-1307.
PMID: 32715987
Patient-specific stem cells derived from somatic cell nuclear transfer (SCNT) embryos or from induced pluripotent stem cells (iPSCs) could be used to treat various diseases with minimal immune rejection. Many...
10.
Elsworth J
J Neural Transm (Vienna)
. 2020 Mar;
127(5):785-791.
PMID: 32172471
The substantial contributions of Dr. Gerald Stern to past and current treatments for Parkinson's disease patients are reviewed, which form the foundation for an evaluation of future options to control...