Matthew R Gazzara
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Explore the profile of Matthew R Gazzara including associated specialties, affiliations and a list of published articles.
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31
Citations
1395
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Recent Articles
11.
Jha A, Aicher J, Gazzara M, Singh D, Barash Y
Genome Biol
. 2020 Jun;
21(1):149.
PMID: 32560708
Despite the success and fast adaptation of deep learning models in biomedical domains, their lack of interpretability remains an issue. Here, we introduce Enhanced Integrated Gradients (EIG), a method to...
12.
Mallory M, McClory S, Chatrikhi R, Gazzara M, Ontiveros R, Lynch K
Nucleic Acids Res
. 2020 Apr;
48(10):5710-5719.
PMID: 32338744
RNA binding proteins (RBPs) frequently regulate the expression of other RBPs in mammalian cells. Such cross-regulation has been proposed to be important to control networks of coordinated gene expression; however,...
13.
Agosto L, Gazzara M, Radens C, Sidoli S, Baeza J, Garcia B, et al.
Genome Res
. 2019 Nov;
29(12):2046-2055.
PMID: 31727681
Alternative pre-mRNA splicing has long been proposed to contribute greatly to proteome complexity. However, the extent to which mature mRNA isoforms are successfully translated into protein remains controversial. Here, we...
14.
Asnani M, Hayer K, Naqvi A, Zheng S, Yang S, Oldridge D, et al.
Leukemia
. 2019 Oct;
34(4):1202-1207.
PMID: 31591467
No abstract available.
15.
Chatrikhi R, Mallory M, Gazzara M, Agosto L, Zhu W, Litterman A, et al.
Cell Rep
. 2019 Sep;
28(11):2795-2806.e3.
PMID: 31509743
The 3' UTR (UTR) of human mRNAs plays a critical role in controlling protein expression and function. Importantly, 3' UTRs of human messages are not invariant for each gene but...
16.
Ehrmann I, Crichton J, Gazzara M, James K, Liu Y, Nagaraja Grellscheid S, et al.
Elife
. 2019 Jan;
8.
PMID: 30674417
Male germ cells of all placental mammals express an ancient nuclear RNA binding protein of unknown function called RBMXL2. Here we find that deletion of the retrogene encoding RBMXL2 blocks...
17.
Black K, Naqvi A, Asnani M, Hayer K, Yang S, Gillespie E, et al.
Nucleic Acids Res
. 2018 Dec;
47(2):1043.
PMID: 30517739
No abstract available.
18.
Black K, Naqvi A, Asnani M, Hayer K, Yang S, Gillespie E, et al.
Nucleic Acids Res
. 2018 Oct;
46(21):11357-11369.
PMID: 30357359
Aberrant splicing is a hallmark of leukemias with mutations in splicing factor (SF)-encoding genes. Here we investigated its prevalence in pediatric B-cell acute lymphoblastic leukemias (B-ALL), where SFs are not...
19.
Thompson M, Munoz-Moreno R, Bhat P, Roytenberg R, Lindberg J, Gazzara M, et al.
Nat Commun
. 2018 Jun;
9(1):2407.
PMID: 29921878
Three of the eight RNA segments encoded by the influenza A virus (IAV) undergo alternative splicing to generate distinct proteins. Previously, we found that host proteins hnRNP K and NS1-BP...
20.
Green C, Gazzara M, Barash Y
Bioinformatics
. 2017 Oct;
34(2):300-302.
PMID: 28968636
Summary: Analysis of RNA sequencing (RNA-Seq) data have highlighted the fact that most genes undergo alternative splicing (AS) and that these patterns are tightly regulated. Many of these events are...