Matthew R Detter
Overview
Explore the profile of Matthew R Detter including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
259
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Recent Articles
1.
Gallione C, Detter M, Sheline A, Christmas H, Lee C, Marchuk D
Hum Genet
. 2022 Apr;
141(11):1761-1769.
PMID: 35488064
Cerebral cavernous malformations (CCM) are vascular malformations consisting of collections of enlarged capillaries occurring in the brain or spinal cord. These vascular malformations can occur sporadically or susceptibility to develop...
2.
Shenkar R, Moore T, Benavides C, Lightle R, Detter M, Hobson N, et al.
J Transl Med
. 2022 Apr;
20(1):160.
PMID: 35382850
No abstract available.
3.
Ren A, Snellings D, Su Y, Hong C, Castro M, Tang A, et al.
Nature
. 2021 Apr;
594(7862):271-276.
PMID: 33910229
Vascular malformations are thought to be monogenic disorders that result in dysregulated growth of blood vessels. In the brain, cerebral cavernous malformations (CCMs) arise owing to inactivation of the endothelial...
4.
Detter M, Shenkar R, Benavides C, Neilson C, Moore T, Lightle R, et al.
Angiogenesis
. 2020 Jul;
23(4):651-666.
PMID: 32710309
Cerebral cavernous malformations (CCMs) are ectatic capillary-venous malformations that develop in approximately 0.5% of the population. Patients with CCMs may develop headaches, focal neurologic deficits, seizures, and hemorrhages. While symptomatic...
5.
Hong C, Tang A, Detter M, Choi J, Wang R, Yang X, et al.
J Exp Med
. 2020 Jul;
217(10).
PMID: 32648916
Cerebral cavernous malformations (CCMs) form following loss of the CCM protein complex in brain endothelial cells due to increased endothelial MEKK3 signaling and KLF2/4 transcription factor expression, but the downstream...
6.
Koskimaki J, Zhang D, Li Y, Saadat L, Moore T, Lightle R, et al.
Acta Neuropathol Commun
. 2019 Aug;
7(1):132.
PMID: 31426861
Cerebral cavernous malformations (CCMs) are dilated capillaries causing epilepsy and stroke. Inheritance of a heterozygous mutation in CCM3/PDCD10 is responsible for the most aggressive familial form of the disease. Here...
7.
Detter M, Snellings D, Marchuk D
Circ Res
. 2018 Oct;
123(10):1143-1151.
PMID: 30359189
Rationale: Vascular malformations arise in vessels throughout the entire body. Causative genetic mutations have been identified for many of these diseases; however, little is known about the mutant cell lineage...
8.
Wetzel-Strong S, Detter M, Marchuk D
J Pathol
. 2016 Nov;
241(2):281-293.
PMID: 27859310
Vascular malformations may arise in any of the vascular beds present in the human body. These lesions vary in location, type, and clinical severity of the phenotype. In recent years,...