Issam A Awad
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Explore the profile of Issam A Awad including associated specialties, affiliations and a list of published articles.
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187
Citations
4727
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Recent Articles
1.
Hage S, Bi D, Kinkade S, Vera Cruz D, Srinath A, Jhaveri A, et al.
J Cereb Blood Flow Metab
. 2025 Jan;
:271678X251314366.
PMID: 39829356
Increases in mean lesional iron content by quantitative susceptibility mapping (QSM) by ≥6% and/or vascular permeability by dynamic contrast enhanced quantitative perfusion (DCEQP) by ≥40% on MRI have been associated...
2.
Hanley D, Ziai W, Vahidy F, Polster S, McBee N, Thompson R, et al.
Stroke
. 2024 Oct;
55(12):2942-2945.
PMID: 39474689
The quotation, attributed to Confucius many centuries ago, in our opinion, applies to the evolving story of defining a primary surgical treatment for spontaneous intracerebral hemorrhage. The precise quote is:...
3.
Pham V, Rodel C, Valentino M, Malinverno M, Paolini A, Munch J, et al.
EMBO Mol Med
. 2024 Oct;
16(11):2827-2855.
PMID: 39402138
Cerebral cavernous malformations (CCMs) are anomalies of the cerebral vasculature. Loss of the CCM proteins CCM1/KRIT1, CCM2, or CCM3/PDCD10 trigger a MAPK-Krüppel-like factor 2 (KLF2) signaling cascade, which induces a...
4.
Alcazar-Felix R, Shenkar R, Benavides C, Bindal A, Srinath A, Li Y, et al.
Transl Stroke Res
. 2024 Jul;
PMID: 38980519
Cerebral cavernous malformation (CCM) is a hemorrhagic cerebrovascular disease where lesions develop in the setting of endothelial mutations of CCM genes, with many cases also harboring somatic PIK3CA gain of...
5.
Frias-Anaya E, Gallego-Gutierrez H, Gongol B, Weinsheimer S, Lai C, Orecchioni M, et al.
Arterioscler Thromb Vasc Biol
. 2024 Apr;
44(6):1246-1264.
PMID: 38660801
Background: Heterogeneity in the severity of cerebral cavernous malformations (CCMs) disease, including brain bleedings and thrombosis that cause neurological disabilities in patients, suggests that environmental, genetic, or biological factors act...
6.
Alcazar-Felix R, Srinath A, Hage S, Bindal A, Ressler A, Pytel P, et al.
J Stroke Cerebrovasc Dis
. 2024 Mar;
33(7):107699.
PMID: 38552890
Background: Radiation treatment for diseases of the brain can result in hemorrhagic adverse radiation effects. The underlying pathologic substrate of brain bleeding after irradiation has not been elucidated, nor potential...
7.
Harris W, Kaiser J, Liao V, Avadhani R, Iadecola C, Falcone G, et al.
Stroke
. 2024 Feb;
55(3):541-547.
PMID: 38299346
Background: Nontraumatic intracerebral hemorrhage (ICH) is independently associated with a long-term increased risk of major arterial ischemic events. While the relationship between ICH location and ischemic risk has been studied,...
8.
Li Y, Girard R, Srinath A, Vera Cruz D, Ciszewski C, Chen C, et al.
Cell Commun Signal
. 2024 Jan;
22(1):23.
PMID: 38195510
Cerebral cavernous malformation (CCM) is a hemorrhagic neurovascular disease with no currently available therapeutics. Prior evidence suggests that different cell types may play a role in CCM pathogenesis. The contribution...
9.
Ayata C, Kim H, Morrison L, Liao J, Gutierrez J, Lopez-Toledano M, et al.
Neurol Genet
. 2024 Jan;
10(1):e200121.
PMID: 38179414
Cerebral cavernous malformations (CCMs) are vascular lesions characterized by a porous endothelium. The lack of a sufficient endothelial barrier can result in microbleeds and frank intracerebral hemorrhage. A primary mechanism...
10.
Hage S, Kinkade S, Girard R, Flemming K, Kim H, Torbey M, et al.
Stroke
. 2023 Dec;
55(1):31-39.
PMID: 38134265
Background: Quantitative susceptibility mapping (QSM) and dynamic contrast-enhanced quantitative perfusion (DCEQP) magnetic resonance imaging sequences assessing iron deposition and vascular permeability were previously correlated with new hemorrhage in cerebral cavernous...