Matthew P Swaffer
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Explore the profile of Matthew P Swaffer including associated specialties, affiliations and a list of published articles.
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15
Citations
459
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Recent Articles
1.
Lanz M, Zhang S, Swaffer M, Ziv I, Gotz L, Kim J, et al.
Nat Struct Mol Biol
. 2024 Jul;
31(12):1859-1871.
PMID: 39048803
Cell size is tightly controlled in healthy tissues and single-celled organisms, but it remains unclear how cell size influences physiology. Increasing cell size was recently shown to remodel the proteomes...
2.
Marinov G, Chen X, Swaffer M, Xiang T, Grossman A, Greenleaf W
Genome Biol
. 2024 May;
25(1):115.
PMID: 38711126
Background: In dinoflagellates, a unique and extremely divergent genomic and nuclear organization has evolved. The highly unusual features of dinoflagellate nuclei and genomes include permanently condensed liquid crystalline chromosomes, primarily...
3.
Swaffer M, Marinov G, Zheng H, Valenzuela L, Tsui C, Jones A, et al.
Cell
. 2023 Nov;
186(24):5254-5268.e26.
PMID: 37944513
A fundamental feature of cellular growth is that total protein and RNA amounts increase with cell size to keep concentrations approximately constant. A key component of this is that global...
4.
Lanz M, Zhang S, Swaffer M, Gotz L, McCarty F, Ziv I, et al.
bioRxiv
. 2023 Oct;
PMID: 37905015
Cell size is tightly controlled in healthy tissues and single-celled organisms, but it remains unclear how size influences cell physiology. Increasing cell size was recently shown to remodel the proteomes...
5.
Marinov G, Chen X, Swaffer M, Xiang T, Grossman A, Greenleaf W
bioRxiv
. 2023 Oct;
PMID: 37781619
In dinoflagellates, a unique and extremely divergent genomic and nuclear organization has evolved. The highly unusual features of dinoflagellate nuclei and genomes include permanently condensed liquid crystalline chromosomes, primarily packaged...
6.
Chatzitheodoridou D, DArio M, Jones I, Pineros L, Serbanescu D, ODonnell F, et al.
J Cell Sci
. 2022 Oct;
135(20).
PMID: 36259425
In April 2022, The Company of Biologists hosted their first post-pandemic in-person Workshop at Buxted Park Country House in the Sussex countryside. The Workshop, entitled 'Cell size and growth: from...
7.
Lanz M, Zatulovskiy E, Swaffer M, Zhang L, Ilerten I, Zhang S, et al.
Mol Cell
. 2022 Aug;
82(17):3255-3269.e8.
PMID: 35987199
Cell size is tightly controlled in healthy tissues, but it is unclear how deviations in cell size affect cell physiology. To address this, we measured how the cell's proteome changes...
8.
Swaffer M, Kim J, Chandler-Brown D, Langhinrichs M, Marinov G, Greenleaf W, et al.
Mol Cell
. 2021 Nov;
81(23):4861-4875.e7.
PMID: 34731644
Biosynthesis scales with cell size such that protein concentrations generally remain constant as cells grow. As an exception, synthesis of the cell-cycle inhibitor Whi5 "sub-scales" with cell size so that...
9.
Koivomagi M, Swaffer M, Turner J, Marinov G, Skotheim J
Science
. 2021 Oct;
374(6565):347-351.
PMID: 34648313
Cell division is thought to be initiated by cyclin-dependent kinases (Cdks) inactivating key transcriptional inhibitors. In budding yeast, the G cyclin Cln3-Cdk1 complex is thought to directly phosphorylate the Whi5...
10.
Swaffer M
Methods Mol Biol
. 2021 Jun;
2329:19-27.
PMID: 34085212
Measuring kinase activity in different in vivo contexts is crucial for understanding the mechanism and functions of protein kinases, such as the cyclin-dependent kinases (Cdks) and other cell cycle kinases....