Matthew P Edgington
Overview
Explore the profile of Matthew P Edgington including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
13
Citations
143
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Anderson M, Gonzalez E, Edgington M, Ang J, Purusothaman D, Shackleford L, et al.
Nat Commun
. 2024 Jan;
15(1):729.
PMID: 38272895
Aedes aegypti is the main vector of several major pathogens including dengue, Zika and chikungunya viruses. Classical mosquito control strategies utilizing insecticides are threatened by rising resistance. This has stimulated...
2.
Anderson M, Gonzalez E, Ang J, Shackleford L, Nevard K, Verkuijl S, et al.
Nat Commun
. 2023 Jan;
14(1):338.
PMID: 36670107
CRISPR/Cas9-based homing gene drives have emerged as a potential new approach to mosquito control. While attempts have been made to develop such systems in Aedes aegypti, none have been able...
3.
Leftwich P, Spurgin L, Harvey-Samuel T, Thomas C, Paladino L, Edgington M, et al.
Philos Trans R Soc Lond B Biol Sci
. 2020 Dec;
376(1818):20190805.
PMID: 33357053
Genetic pest management (GPM) methods involve releasing modified versions of a pest species to mate with wild pests in the target area. Proposed for a wide range of applications in...
4.
Edgington M, Harvey-Samuel T, Alphey L
Sci Rep
. 2020 Nov;
10(1):20520.
PMID: 33239631
A wide range of gene drive mechanisms have been proposed that are predicted to increase in frequency within a population even when they are deleterious to individuals carrying them. This...
5.
Edgington M, Harvey-Samuel T, Alphey L
Evol Appl
. 2020 Sep;
13(8):1939-1948.
PMID: 32908596
CRISPR-based gene drives bias inheritance in their favour by inducing double-stranded breaks (DSBs) at wild-type homologous loci and using the drive transgene as a repair template-converting drive heterozygotes into homozygotes....
6.
Leftwich P, Edgington M, Chapman T
Proc Biol Sci
. 2020 Sep;
287(1934):20200820.
PMID: 32873208
Sequencing technologies have fuelled a rapid rise in descriptions of microbial communities associated with hosts, but what is often harder to ascertain is the evolutionary significance of these symbioses. Here,...
7.
Edgington M, Alphey L
J Theor Biol
. 2019 Jul;
479:14-21.
PMID: 31260669
A range of gene drive systems have been proposed that are predicted to increase their frequency and that of associated desirable genetic material even if they confer a fitness cost...
8.
Leftwich P, Edgington M, Harvey-Samuel T, Paladino L, Norman V, Alphey L
Biochem Soc Trans
. 2018 Sep;
46(5):1203-1212.
PMID: 30190331
Mosquito-borne diseases, such as malaria, dengue and chikungunya, cause morbidity and mortality around the world. Recent advances in gene drives have produced control methods that could theoretically modify all populations...
9.
Edgington M, Alphey L
PLoS Comput Biol
. 2018 Mar;
14(3):e1006059.
PMID: 29570717
A number of different genetics-based vector control methods have been proposed. Two approaches currently under development in Aedes aegypti mosquitoes are the two-locus engineered underdominance and killer-rescue gene drive systems....
10.
Edgington M, Tindall M
Bull Math Biol
. 2018 Feb;
80(4):758-787.
PMID: 29404879
We undertake a detailed mathematical analysis of a recent nonlinear ordinary differential equation (ODE) model describing the chemotactic signalling cascade within an Escherichia coli cell. The model includes a detailed...