Marcus J Tindall
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Explore the profile of Marcus J Tindall including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
250
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Recent Articles
1.
Dodd J, Sweby P, Mayes S, Murchie E, Karunaratne A, Massawe F, et al.
J Theor Biol
. 2022 Dec;
560:111373.
PMID: 36509139
A principal objective in agriculture is to maximise food production; this is particularly relevant with the added demands of an ever increasing population, coupled with the unpredictability that climate change...
2.
Vavouraki N, Tomkins J, Kara E, Houlden H, Hardy J, Tindall M, et al.
iScience
. 2021 Jun;
24(5):102484.
PMID: 34113825
The Hereditary Spastic Paraplegias are a group of neurodegenerative diseases characterized by spasticity and weakness in the lower body. Owing to the combination of genetic diversity and variable clinical presentation,...
3.
Mazet F, Tindall M, Gibbins J, Fry M
Sci Rep
. 2020 Aug;
10(1):13244.
PMID: 32764630
The phosphatidylinositol (PI) cycle is central to eukaryotic cell signaling. Its complexity, due to the number of reactions and lipid and inositol phosphate intermediates involved makes it difficult to analyze...
4.
Cucurull-Sanchez L, Chappell M, Chelliah V, Cheung S, Derks G, Penney M, et al.
CPT Pharmacometrics Syst Pharmacol
. 2019 Jan;
8(5):259-272.
PMID: 30667172
The lack of standardization in the way that quantitative and systems pharmacology (QSP) models are developed, tested, and documented hinders their reproducibility, reusability, and expansion or reduction to alternative contexts....
5.
Maldonado E, Fisher C, Mazzatti D, Barber A, Tindall M, Plant N, et al.
NPJ Syst Biol Appl
. 2018 Aug;
4:33.
PMID: 30131870
Non-alcoholic fatty liver disease (NAFLD) is a serious public health issue associated with high fat, high sugar diets. However, the molecular mechanisms mediating NAFLD pathogenesis are only partially understood. Here...
6.
Snowden T, van der Graaf P, Tindall M
J Pharmacokinet Pharmacodyn
. 2018 Mar;
45(4):537-555.
PMID: 29582349
In this paper we present a framework for the reduction and linking of physiologically based pharmacokinetic (PBPK) models with models of systems biology to describe the effects of drug administration...
7.
Edgington M, Tindall M
Bull Math Biol
. 2018 Feb;
80(4):758-787.
PMID: 29404879
We undertake a detailed mathematical analysis of a recent nonlinear ordinary differential equation (ODE) model describing the chemotactic signalling cascade within an Escherichia coli cell. The model includes a detailed...
8.
Pool F, Currie R, Sweby P, Salazar J, Tindall M
J Theor Biol
. 2018 Jan;
443:157-176.
PMID: 29355536
We formulate, parameterise and analyse a mathematical model of the mevalonate pathway, a key pathway in the synthesis of cholesterol. Of high clinical importance, the pathway incorporates rate limiting enzymatic...
9.
Dede E, Tindall M, Cherrie J, Hankin S, Collins C
Environ Toxicol Pharmacol
. 2017 Dec;
57:104-114.
PMID: 29253785
Biological monitoring and physiologically-based pharmacokinetic (PBPK) modelling are useful complementary tools in quantifying human exposure to elements in the environment. In this work, we used PBPK models to determine the...
10.
Snowden T, van der Graaf P, Tindall M
Bull Math Biol
. 2017 Jun;
79(7):1449-1486.
PMID: 28656491
Complex models of biochemical reaction systems have become increasingly common in the systems biology literature. The complexity of such models can present a number of obstacles for their practical use,...