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Sebald A N Verkuijl

Explore the profile of Sebald A N Verkuijl including associated specialties, affiliations and a list of published articles. Areas
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Articles 7
Citations 82
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Recent Articles
1.
Anderson M, Gonzalez E, Edgington M, Ang J, Purusothaman D, Shackleford L, et al.
Nat Commun . 2024 Jan; 15(1):729. PMID: 38272895
Aedes aegypti is the main vector of several major pathogens including dengue, Zika and chikungunya viruses. Classical mosquito control strategies utilizing insecticides are threatened by rising resistance. This has stimulated...
2.
Anderson M, Gonzalez E, Ang J, Shackleford L, Nevard K, Verkuijl S, et al.
Nat Commun . 2023 Jan; 14(1):338. PMID: 36670107
CRISPR/Cas9-based homing gene drives have emerged as a potential new approach to mosquito control. While attempts have been made to develop such systems in Aedes aegypti, none have been able...
3.
Verkuijl S, Gonzalez E, Li M, Ang J, Kandul N, Anderson M, et al.
Nat Commun . 2022 Nov; 13(1):7145. PMID: 36414618
CRISPR/Cas gene drives can bias transgene inheritance through different mechanisms. Homing drives are designed to replace a wild-type allele with a copy of a drive element on the homologous chromosome....
4.
Verkuijl S, Anderson M, Alphey L, Bonsall M
PLoS Genet . 2022 Sep; 18(9):e1010370. PMID: 36121880
The introgression of genetic traits through gene drive may serve as a powerful and widely applicable method of biological control. However, for many applications, a self-perpetuating gene drive that can...
5.
Verkuijl S, Ang J, Alphey L, Bonsall M, Anderson M
Front Bioeng Biotechnol . 2022 Apr; 10:856981. PMID: 35419354
Making discrete and precise genetic changes to wild populations has been proposed as a means of addressing some of the world's most pressing ecological and public health challenges caused by...
6.
Ang J, Nevard K, Ireland R, Purusothaman D, Verkuijl S, Shackleford L, et al.
PLoS Genet . 2022 Feb; 18(2):e1010060. PMID: 35180218
The increasing prevalence of insecticide resistance and the ongoing global burden of vector-borne diseases have encouraged new efforts in mosquito control. For Aedes aegypti, the most important arboviral vector, integration...
7.
Anderson M, Purcell J, Verkuijl S, Norman V, Leftwich P, Harvey-Samuel T, et al.
ACS Synth Biol . 2020 Mar; 9(3):678-681. PMID: 32129976
CRISPR-Cas9-based "gene drive" technologies have been proposed as a novel and effective means of controlling human diseases vectored by mosquitoes. However, more complex designs than those demonstrated to date-and an...