Matthew N Davies
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Explore the profile of Matthew N Davies including associated specialties, affiliations and a list of published articles.
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36
Citations
1637
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Recent Articles
1.
Zito A, Davies M, Tsai P, Roberts S, Andres-Ejarque R, Nardone S, et al.
Nat Commun
. 2019 Nov;
10(1):5339.
PMID: 31767861
Female somatic X-chromosome inactivation (XCI) balances the X-linked transcriptional dosages between the sexes. Skewed XCI toward one parental X has been observed in several complex human traits, but the extent...
2.
Woolston A, Khan K, Spain G, Barber L, Griffiths B, Gonzalez-Exposito R, et al.
Cancer Cell
. 2019 Jul;
36(1):35-50.e9.
PMID: 31287991
Despite biomarker stratification, the anti-EGFR antibody cetuximab is only effective against a subgroup of colorectal cancers (CRCs). This genomic and transcriptomic analysis of the cetuximab resistance landscape in 35 RAS...
3.
Mansukhani S, Barber L, Kleftogiannis D, Moorcraft S, Davidson M, Woolston A, et al.
Clin Chem
. 2018 Aug;
64(11):1626-1635.
PMID: 30150316
Background: Circulating free DNA sequencing (cfDNA-Seq) can portray cancer genome landscapes, but highly sensitive and specific technologies are necessary to accurately detect mutations with often low variant frequencies. Methods: We...
4.
Vinuela A, Brown A, Buil A, Tsai P, Davies M, Bell J, et al.
Hum Mol Genet
. 2017 Dec;
27(4):732-741.
PMID: 29228364
Changes in the mean and variance of gene expression with age have consequences for healthy aging and disease development. Age-dependent changes in phenotypic variance have been associated with a decline...
5.
Devall M, Smith R, Jeffries A, Hannon E, Davies M, Schalkwyk L, et al.
Clin Epigenetics
. 2017 May;
9:47.
PMID: 28473874
Background: DNA methylation is an important epigenetic mechanism involved in gene regulation, with alterations in DNA methylation in the nuclear genome being linked to numerous complex diseases. Mitochondrial DNA methylation...
6.
Davies M, Pere H, Bosschem I, Haesebrouck F, Flahou B, Tartour E, et al.
Methods Mol Biol
. 2016 Oct;
1494:107-125.
PMID: 27718189
Adjuvants are substances that boost the protective immune response to vaccine antigens. The majority of known adjuvants have been identified through the use of empirical approaches. Our aim was to...
7.
Lipinski K, Barber L, Davies M, Ashenden M, Sottoriva A, Gerlinger M
Trends Cancer
. 2016 Mar;
2(1):49-63.
PMID: 26949746
The ability to predict the future behavior of an individual cancer is crucial for precision cancer medicine. The discovery of extensive intratumor heterogeneity and ongoing clonal adaptation in human tumors...
8.
Davies M, Verdi S, Burri A, Trzaskowski M, Lee M, Hettema J, et al.
PLoS One
. 2015 Aug;
10(8):e0134865.
PMID: 26274327
Generalised Anxiety Disorder (GAD) is a common anxiety-related diagnosis, affecting approximately 5% of the adult population. One characteristic of GAD is a high degree of anxiety sensitivity (AS), a personality...
9.
Barber L, Davies M, Gerlinger M
Curr Opin Genet Dev
. 2015 Jan;
30:1-6.
PMID: 25555261
Intratumour heterogeneity complicates biomarker discovery and treatment personalization, and pervasive cancer evolution is a key mechanism leading to therapy failure and patient death. Thus, understanding subclonal heterogeneity architectures and cancer...
10.
Buil A, Brown A, Lappalainen T, Vinuela A, Davies M, Zheng H, et al.
Nat Genet
. 2014 Dec;
47(1):88-91.
PMID: 25436857
Understanding the genetic architecture of gene expression is an intermediate step in understanding the genetic architecture of complex diseases. RNA sequencing technologies have improved the quantification of gene expression and...