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Matthew N Davies

Explore the profile of Matthew N Davies including associated specialties, affiliations and a list of published articles. Areas
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Recent Articles
11.
Davies M, Krause L, Bell J, Gao F, Ward K, Wu H, et al.
Genome Biol . 2014 Apr; 15(4):R56. PMID: 24694013
Background: Although genetic variation is believed to contribute to an individual's susceptibility to major depressive disorder, genome-wide association studies have not yet identified associations that could explain the full etiology...
12.
Glass D, Vinuela A, Davies M, Ramasamy A, Parts L, Knowles D, et al.
Genome Biol . 2013 Jul; 14(7):R75. PMID: 23889843
Background: Previous studies have demonstrated that gene expression levels change with age. These changes are hypothesized to influence the aging rate of an individual. We analyzed gene expression changes with...
13.
Davies M, Guan P, Blythe M, Salomon J, Toseland C, Hattotuwagama C, et al.
Expert Opin Drug Discov . 2013 Mar; 2(1):19-35. PMID: 23496035
Throughout time functional immunology has accumulated vast amounts of quantitative and qualitative data relevant to the design and discovery of vaccines. Such data includes, but is not limited to, components...
14.
Davies M, Volta M, Pidsley R, Lunnon K, Dixit A, Lovestone S, et al.
Genome Biol . 2012 Jun; 13(6):R43. PMID: 22703893
Background: Dynamic changes to the epigenome play a critical role in establishing and maintaining cellular phenotype during differentiation, but little is known about the normal methylomic differences that occur between...
15.
Davies M, Gloriam D, Secker A, Freitas A, Timmis J, Flower D
Curr Top Med Chem . 2011 Apr; 11(15):1994-2009. PMID: 21470173
The G-protein coupled receptors--or GPCRs--comprise simultaneously one of the largest and one of the most multi-functional protein families known to modern-day molecular bioscience. From a drug discovery and pharmaceutical industry...
16.
Flower D, Phadwal K, Macdonald I, Coveney P, Davies M, Wan S
Immunome Res . 2010 Nov; 6 Suppl 2:S4. PMID: 21067546
Atomistic Molecular Dynamics provides powerful and flexible tools for the prediction and analysis of molecular and macromolecular systems. Specifically, it provides a means by which we can measure theoretically that...
17.
Flower D, Macdonald I, Ramakrishnan K, Davies M, Doytchinova I
Immunome Res . 2010 Nov; 6 Suppl 2:S1. PMID: 21067543
Immunoinformatics is an emergent branch of informatics science that long ago pullulated from the tree of knowledge that is bioinformatics. It is a discipline which applies informatic techniques to problems...
18.
Davies M, Meaburn E, Schalkwyk L
Brief Funct Genomics . 2010 Sep; 9(5-6):385-90. PMID: 20861160
Gene Set Enrichment (GSE) is a computational technique which determines whether a priori defined set of genes show statistically significant differential expression between two phenotypes. Currently, the gene sets used...
19.
Davies M, Lawn S, Whatley S, Fernandes C, Williams R, Schalkwyk L
Front Neurosci . 2010 Jun; 3:54. PMID: 20582281
Microarrays are designed to measure genome-wide differences in gene expression. In cases where a tissue is not accessible for analysis (e.g. human brain), it is of interest to determine whether...
20.
Schalkwyk L, Meaburn E, Smith R, Dempster E, Jeffries A, Davies M, et al.
Am J Hum Genet . 2010 Feb; 86(2):196-212. PMID: 20159110
DNA methylation is assumed to be complementary on both alleles across the genome, although there are exceptions, notably in regions subject to genomic imprinting. We present a genome-wide survey of...