Matthew G Dowgiallo
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Explore the profile of Matthew G Dowgiallo including associated specialties, affiliations and a list of published articles.
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5
Citations
28
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Recent Articles
1.
Morgan C, Kang Y, Green A, Smith K, Dowgiallo M, Miller B, et al.
PLoS Biol
. 2023 May;
21(5):e3002091.
PMID: 37192172
The streptothricin natural product mixture (also known as nourseothricin) was discovered in the early 1940s, generating intense initial interest because of excellent gram-negative activity. Here, we establish the activity spectrum...
2.
Dowgiallo M, Miller B, Kassu M, Smith K, Fetigan A, Guo J, et al.
Chem Sci
. 2022 Apr;
13(12):3447-3453.
PMID: 35432870
A convergent, diversity-enabling total synthesis of the natural product streptothricin F has been achieved. Herein, we describe the potent antimicrobial activity of streptothricin F and highlight the importance of a...
3.
Aluri K, Hossain M, Kanetkar N, Miller B, Dowgiallo M, Sivasankar D, et al.
Bioconjug Chem
. 2021 Feb;
32(3):584-594.
PMID: 33606505
We recently reported that cyclic thiosulfinates are cysteine selective cross-linkers that avoid the "dead-end" modifications that contribute to other cross-linkers' toxicity. In this study, we generalize the chemistry of cyclic...
4.
Smith K, Dowgiallo M, Chiaraviglio L, Parvatkar P, Kim C, Manetsch R, et al.
SLAS Discov
. 2019 Jul;
24(8):842-853.
PMID: 31268804
Carbapenem-resistant Enterobacteriaceae (CRE) are an emerging antimicrobial resistance threat for which few if any therapeutic options remain. Identification of new agents that either inhibit CRE or restore activity of existing...
5.
Donnelly D, Dowgiallo M, Salisbury J, Aluri K, Iyengar S, Chaudhari M, et al.
J Am Chem Soc
. 2018 Jun;
140(24):7377-7380.
PMID: 29851341
This work addresses the need for chemical tools that can selectively form cross-links. Contemporary thiol-selective cross-linkers, for example, modify all accessible thiols, but only form cross-links between a subset. The...