Jared R Auclair
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Explore the profile of Jared R Auclair including associated specialties, affiliations and a list of published articles.
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24
Citations
585
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Recent Articles
1.
Hossain M, Brahme R, Miller B, Amin J, de Barros M, Schneider J, et al.
Nat Commun
. 2025 Feb;
16(1):1777.
PMID: 39971904
Covalent drug discovery efforts are growing rapidly but have major unaddressed limitations. These include high false positive rates during hit-to-lead identification; the inherent uncoupling of covalent drug concentration and effect...
2.
Sadiki A, Liu S, Vaidya S, Kercher E, Lang R, McIsaac J, et al.
Bioconjug Chem
. 2024 Mar;
35(4):465-471.
PMID: 38499390
A versatile chemo-enzymatic tool to site-specifically modify native (nonengineered) antibodies is using transglutaminase (TGase, E.C. 2.3.2.13). With various amines as cosubstrates, this enzyme converts the unsubstituted side chain amide of...
3.
Hossain M, Sarin R, Donnelly D, Miller B, Weiss A, McAlary L, et al.
PLoS Biol
. 2024 Jan;
22(1):e3002462.
PMID: 38289969
Mutations in the gene encoding Cu-Zn superoxide dismutase 1 (SOD1) cause a subset of familial amyotrophic lateral sclerosis (fALS) cases. A shared effect of these mutations is that SOD1, which...
4.
Pinkhover N, Pontbriand K, Fletcher K, Sanchez E, Okello K, Garvey L, et al.
Microbiol Spectr
. 2024 Jan;
12(2):e0348423.
PMID: 38206048
The development of biosurveillance programs with strong analytical performance and economically accessible protocols is essential for monitoring viral pathogens. Throughout the COVID-19 pandemic, whole-genome sequencing (WGS) has been the prevailing...
5.
Baker P, Cathey T, Auclair J
Ther Innov Regul Sci
. 2023 Nov;
58(1):11-15.
PMID: 37991704
The COVID-19 pandemic forced industry and national regulatory authorities (NRAs) to think about innovative ways to ensure business continuity, including Good Manufacturing Practices (GMP) inspections. Even prior to COVID-19, it...
6.
Sharmin M, Manivannan M, Woo D, Sorel O, Auclair J, Gandhi M, et al.
Front Public Health
. 2023 Oct;
11:1185720.
PMID: 37841738
Background: SARS-CoV-2 PCR testing data has been widely used for COVID-19 surveillance. Existing COVID-19 forecasting models mainly rely on case counts obtained from qPCR results, even though the binary PCR...
7.
Kumari R, Lim J, Sullivan M, Malampy R, Baush C, Smolina I, et al.
Diagnostics (Basel)
. 2022 Sep;
12(9).
PMID: 36140653
SARS-CoV-2 has remained a global health burden, primarily due to the continuous evolution of different mutant strains. These mutations present challenges to the detection of the virus, as the target...
8.
Petros B, Turcinovic J, Welch N, White L, Kolaczyk E, Bauer M, et al.
Clin Infect Dis
. 2022 May;
76(3):e400-e408.
PMID: 35616119
Background: The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is highly transmissible in vaccinated and unvaccinated populations. The dynamics that govern its establishment and propensity toward fixation...
9.
Ganz T, Donner R, Hines K, Waithe-Alleyne M, Slate D, Abel G, et al.
J Mol Diagn
. 2021 Sep;
23(12):1691-1698.
PMID: 34562617
Population testing for severe acute respiratory syndrome coronavirus 2 is necessary because of the potential for viral transmission from asymptomatic cases, yet the scarcity of reagents and equipment has increased...
10.
Chanin R, Nickerson K, Llanos-Chea A, Sistrunk J, Rasko D, Kumar D, et al.
mSphere
. 2019 Nov;
4(6).
PMID: 31722995
The species are Gram-negative, facultative intracellular pathogens that invade the colonic epithelium and cause significant diarrheal disease. Despite extensive research on the pathogen, a comprehensive understanding of how initiates contact...