Edward W Yu
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Explore the profile of Edward W Yu including associated specialties, affiliations and a list of published articles.
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97
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2278
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Recent Articles
1.
Gregor W, Maharjan R, Zhang Z, Chiaraviglio L, Sastry N, Cui M, et al.
mBio
. 2025 Mar;
:e0382624.
PMID: 40042268
Importance: Here, we report the cryo-electron microscopy structure of the MexY multidrug efflux pump, posing the possibility that this pump is capable of capturing antibiotics from both the central cavity...
2.
Zhang Z, Lyu M, Han X, Bandara S, Cui M, Istvan E, et al.
Sci Adv
. 2024 Dec;
10(51):eadq6651.
PMID: 39693420
Malaria, a devastating parasitic infection, is the leading cause of death in many developing countries. Unfortunately, the most deadliest causative agent of malaria, , has developed resistance to nearly all...
3.
Han X, Zhang Z, Su C, Lyu M, Miyagi M, Yu E, et al.
bioRxiv
. 2024 Dec;
PMID: 39651215
Platelets fulfill their essential physiological roles sensing the extracellular environment through their membrane proteins. The native membrane environment provides essential regulatory cues that impact the protein structure and mechanism of...
4.
Dai L, Wu Z, Sahin O, Zhao S, Yu E, Zhang Q
Proc Natl Acad Sci U S A
. 2024 Nov;
121(51):e2415823121.
PMID: 39602248
The resistance-nodulation-cell division (RND) superfamily of multidrug efflux systems are important players in mediating antibiotic resistance in gram-negative pathogens. , a major enteric pathogen, utilizes an RND-type transporter system, CmeABC,...
5.
Maharjan R, Zhang Z, Klenotic P, Gregor W, Purdy G, Yu E
mBio
. 2024 Oct;
15(12):e0303524.
PMID: 39480109
Importance: The emergence and spread of multidrug-resistant tuberculosis (TB) present enormous challenges to the global public health. The causative agent, , has now infected more than one-third of the world's...
6.
Maharjan R, Zhang Z, Klenotic P, Gregor W, Tringides M, Cui M, et al.
PLoS Biol
. 2024 Oct;
22(10):e3002874.
PMID: 39423221
The Mycobacterium tuberculosis (Mtb) pathogen, the causative agent of the airborne infection tuberculosis (TB), harbors a number of mycobacterial membrane protein large (MmpL) transporters. These membrane proteins can be separated...
7.
Walton B, Abbondante S, Marshall M, Dobruchowska J, Alvi A, Gallagher L, et al.
bioRxiv
. 2024 Aug;
PMID: 39185188
Bacteria in nature can exist in multicellular communities called biofilms. Biofilms also form in the course of many infections. infections frequently involve biofilms, which contribute materially to the difficulty to...
8.
Su C, Zhang Z, Lyu M, Cui M, Yu E
PLoS Biol
. 2024 Aug;
22(8):e3002719.
PMID: 39167625
The band 3 transporter is a critical integral membrane protein of the red blood cell (RBC), as it is responsible for catalyzing the exchange of bicarbonate and chloride anions across...
9.
Klenotic P, Yu E
Microbiol Mol Biol Rev
. 2024 Mar;
88(2):e0019823.
PMID: 38551344
SUMMARYInfectious bacteria have both intrinsic and acquired mechanisms to combat harmful biocides that enter the cell. Through adaptive pressures, many of these pathogens have become resistant to many, if not...
10.
Masse M, Hutchinson R, Morgan C, Allaman H, Guan H, Yu E, et al.
ACS Cent Sci
. 2024 Mar;
10(2):385-401.
PMID: 38435509
Interactions between ribosome-bound nascent chains (RNCs) and ribosomal components are critical to elucidate the mechanism of cotranslational protein folding. Nascent protein-ribosome contacts within the ribosomal exit tunnel were previously assessed...