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Juliel Espinosa

Explore the profile of Juliel Espinosa including associated specialties, affiliations and a list of published articles. Areas
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Articles 6
Citations 227
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Recent Articles
1.
Griffin M, Klupt S, Espinosa J, Hang H
Cell Chem Biol . 2022 Nov; 30(5):436-456. PMID: 36417916
The bacterial cell wall is composed of a highly crosslinked matrix of glycopeptide polymers known as peptidoglycan that dictates bacterial cell morphology and protects against environmental stresses. Regulation of peptidoglycan...
2.
Griffin M, Espinosa J, Becker J, Luo J, Carroll T, Jha J, et al.
Science . 2021 Aug; 373(6558):1040-1046. PMID: 34446607
The antitumor efficacy of cancer immunotherapy can correlate with the presence of certain bacterial species within the gut microbiome. However, many of the molecular mechanisms that influence host response to...
3.
Canfield G, Chatterjee A, Espinosa J, Mangalea M, Sheriff E, Keidan M, et al.
Antimicrob Agents Chemother . 2021 Mar; 65(5). PMID: 33649110
, a commensal of the human intestine, has emerged as a hospital-adapted, multi-drug resistant (MDR) pathogen. Bacteriophages (phages), natural predators of bacteria, have regained attention as therapeutics to stem the...
4.
Espinosa J, Lin T, Estrella Y, Kim B, Molina H, Hang H
Biochemistry . 2020 Nov; 59(46):4470-4480. PMID: 33136372
Peptidoglycan is a vital component of the bacterial cell wall, and its dynamic remodeling by NlpC/p60 hydrolases is crucial for proper cell division and survival. Beyond these essential functions, we...
5.
Kim B, Espinosa J, Hang H
Methods Enzymol . 2020 May; 638:109-127. PMID: 32416909
The NlpC/p60-family of peptidoglycan hydrolases are key enzymes that facilitate bacterial cell division and also modulate microbe-host interactions. These endopeptidases utilize conserved Cys-His residues in their active site and are...
6.
Kim B, Wang Y, Hespen C, Espinosa J, Salje J, Rangan K, et al.
Elife . 2019 Apr; 8. PMID: 30969170
We discovered that (), a ubiquitous commensal bacterium, and its secreted peptidoglycan hydrolase (SagA) were sufficient to enhance intestinal barrier function and pathogen tolerance, but the precise biochemical mechanism was...