Ying-Han Chen
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Explore the profile of Ying-Han Chen including associated specialties, affiliations and a list of published articles.
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40
Citations
1156
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Recent Articles
1.
Chen Y, Zaldana K, Yeung F, Vujkovic-Cvijin I, Downie A, Lin J, et al.
Sci Adv
. 2025 Mar;
11(10):eads2364.
PMID: 40053586
Inbred mice used for biomedical research display an underdeveloped immune system compared with adult humans, which is attributed in part to the artificial laboratory environment. Despite representing a central component...
2.
Downie A, Barre R, Robinson A, Yang J, Chen Y, Lin J, et al.
Discov Immunol
. 2024 Jul;
3(1):kyae010.
PMID: 39045514
The study of immune phenotypes in wild animals is beset by numerous methodological challenges, with assessment of detailed aspects of phenotype difficult to impossible. This constrains the ability of disease...
3.
Oyesola O, Downie A, Howard N, Barre R, Kiwanuka K, Zaldana K, et al.
Nat Immunol
. 2024 Jun;
25(7):1270-1282.
PMID: 38877178
The relative and synergistic contributions of genetics and environment to interindividual immune response variation remain unclear, despite implications in evolutionary biology and medicine. Here we quantify interactive effects of genotype...
4.
Liang S, Sircaik S, Dainis J, Kakade P, Penumutchu S, McDonough L, et al.
Nature
. 2024 Mar;
627(8004):620-627.
PMID: 38448595
The fungus Candida albicans frequently colonizes the human gastrointestinal tract, from which it can disseminate to cause systemic disease. This polymorphic species can transition between growing as single-celled yeast and...
5.
Downie A, Oyesola O, Barre R, Caudron Q, Chen Y, Dennis E, et al.
Sci Adv
. 2023 Dec;
9(51):eadh8310.
PMID: 38134275
Environmental influences on immune phenotypes are well-documented, but our understanding of which elements of the environment affect immune systems, and how, remains vague. Behaviors, including socializing with others, are central...
6.
Jang K, Heaney T, London M, Ding Y, Putzel G, Yeung F, et al.
Cell Host Microbe
. 2023 Aug;
31(9):1450-1468.e8.
PMID: 37652008
Loss of antimicrobial proteins such as REG3 family members compromises the integrity of the intestinal barrier. Here, we demonstrate that overproduction of REG3 proteins can also be detrimental by reducing...
7.
Chen Y, Yeung F, Lacey K, Zaldana K, Lin J, Bee G, et al.
Sci Immunol
. 2023 Jun;
8(84):eadd6910.
PMID: 37352372
The paucity of blood granulocyte populations such as neutrophils in laboratory mice is a notable difference between this model organism and humans, but the cause of this species-specific difference is...
8.
Ming Y, Lv X, Chen Y, Liu Y
Chem Commun (Camb)
. 2023 Jun;
59(56):8711-8714.
PMID: 37350153
A highly regio-, chemo-, and stereoselective cascade process initiated by enantioselective iminium-catalyzed conjugate addition of 2-hydroxycinnamaldehydes and 2-oxocarboxylic esters is presented. Normal cinnamaldehydes are not reactive under the same reaction...
9.
Oyesola O, Downie A, Howard N, Barre R, Kiwanuka K, Zaldana K, et al.
bioRxiv
. 2023 Mar;
PMID: 36993484
The relative and synergistic contributions of genetics and environment to inter-individual immune response variation remain unclear, despite its implications for understanding both evolutionary biology and medicine. Here, we quantify interactive...
10.
Jang K, Heaney T, London M, Ding Y, Yeung F, Ercelen D, et al.
bioRxiv
. 2023 Feb;
PMID: 36778381
Loss of antimicrobial proteins such as REG3 family members compromises the integrity of the intestinal barrier. Here, we demonstrate that overproduction of REG3 proteins can also be detrimental by reducing...