Matt Jacobsen
Overview
Explore the profile of Matt Jacobsen including associated specialties, affiliations and a list of published articles.
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14
Citations
564
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0
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Recent Articles
1.
Palazzi X, Anger L, Boulineau T, Grevot A, Guffroy M, Henson K, et al.
Regul Toxicol Pharmacol
. 2024 Apr;
150():105632.
PMID: 38679316
The replacement of a proportion of concurrent controls by virtual controls in nonclinical safety studies has gained traction over the last few years. This is supported by foundational work, encouraged...
2.
Grevot A, Boisclair J, Guffroy M, Hall P, Pohlmeyer-Esch G, Jacobsen M, et al.
Toxicol Pathol
. 2024 Jan;
51(6):390-396.
PMID: 38293937
In the last decade, numerous initiatives have emerged worldwide to reduce the use of animals in drug development, including more recently the introduction of Virtual Control Groups (VCGs) concept for...
3.
Jacobsen M, Lewis A, Baily J, Fraser A, Rudmann D, Ryan S
Toxicol Pathol
. 2021 Jun;
49(6):1164-1173.
PMID: 34060353
The approach undertaken to deliver a Good Laboratory Practice (GLP) validation of whole slide images (WSIs) and the associated workflow for the digital primary evaluation and peer review of a...
4.
Bradley A, Jacobsen M
Toxicol Pathol
. 2019 Jan;
47(2):100-107.
PMID: 30636543
Whole slide imaging (WSI) technology has advanced to a point where it has replaced the glass slide as the primary means of pathology evaluation within many areas of medical pathology....
5.
Ferrell Ramos M, Baker J, Atzpodien E, Bach U, Brassard J, Cartwright J, et al.
J Toxicol Pathol
. 2018 Aug;
31(3 Suppl):97S-214S.
PMID: 30158741
No abstract available.
6.
Balmus G, Larrieu D, Barros A, Collins C, Abrudan M, Demir M, et al.
Nat Commun
. 2018 Apr;
9(1):1700.
PMID: 29703891
Hutchinson-Gilford Progeria Syndrome (HGPS) is a rare, but devastating genetic disease characterized by segmental premature aging, with cardiovascular disease being the main cause of death. Cells from HGPS patients accumulate...
7.
Balmus G, Barros A, Wijnhoven P, Lescale C, Hasse H, Boroviak K, et al.
Genes Dev
. 2016 Nov;
30(19):2152-2157.
PMID: 27798842
PAXX was identified recently as a novel nonhomologous end-joining DNA repair factor in human cells. To characterize its physiological roles, we generated Paxx-deficient mice. Like Xlf mice, Paxx mice are...
8.
Roberts R, Callander R, Duffy P, Jacobsen M, Knight R, Boobis A
Regul Toxicol Pharmacol
. 2015 Nov;
73(3):737-46.
PMID: 26517939
We have previously reported the profile of target organs (defined as organs showing histopathological changes) in rodent and non-rodent toxicity studies conducted prior to first-time-in-man (FTiM) for 77 AstraZeneca candidate...
9.
Samuelsson K, Pickup K, Sarda S, Foster J, Randall K, Abrahamsson A, et al.
Xenobiotica
. 2014 Jan;
44(2):186-95.
PMID: 24417752
1. The biotransformation, hepatic transporter and blood chemistry effects of troglitazone were investigated following 7 days of dosing at 600 mg/kg/day to chimeric murinized or humanized FRG mice, Mo-FRG and...
10.
Coulson M, Bickerton S, Betts C, Jacobsen M, Stewart J, Chapin R, et al.
Birth Defects Res B Dev Reprod Toxicol
. 2013 Jan;
98(1):4-16.
PMID: 23349040
Background: A cross-laboratory analytic evaluation of a commercially available human inhibin B ELISA for measuring inhibin B in rat serum and plasma has been undertaken. Methods: Dilution linearity, spiked recovery,...