Sunil Sarda
Overview
Explore the profile of Sunil Sarda including associated specialties, affiliations and a list of published articles.
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Articles
21
Citations
123
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Recent Articles
1.
Lucas S, Milbradt A, Blackwell J, Bonomo S, Brierley A, Cassar D, et al.
J Med Chem
. 2024 Jun;
67(13):11209-11225.
PMID: 38916990
Covalent hit identification is a viable approach to identify chemical starting points against difficult-to-drug targets. While most researchers screen libraries of <2k electrophilic fragments, focusing on lead-like compounds can be...
2.
Avila C, Cassani C, Kogej T, Mazuela J, Sarda S, Clayton A, et al.
Chem Sci
. 2022 Nov;
13(41):12087-12099.
PMID: 36349112
For the discovery of new candidate molecules in the pharmaceutical industry, library synthesis is a critical step, in which library size, diversity, and time to synthesise are fundamental. In this...
3.
Torres F, Walser R, Kaderli J, Rossi E, Bobby R, Packer M, et al.
J Med Chem
. 2022 Mar;
65(7):5565-5574.
PMID: 35357834
Structure-based drug discovery (SBDD) largely relies on structural information from X-ray crystallography because traditional NMR structure calculation methods are too time consuming to be aligned with typical drug discovery timelines....
4.
Green C, Spencer P, Sarda S
Drug Discov Today
. 2020 Oct;
26(1):5-9.
PMID: 33031945
Faced with ageing infrastructure and ever-increasing demands from hit discovery and lead optimisation functions, AstraZeneca has chosen to develop innovative technologies and process solutions to support the future of drug...
5.
Pickup K, Martin S, Partridge E, Jones H, Wills J, Schulz-Utermoehl T, et al.
Arch Toxicol
. 2016 Nov;
91(7):2643-2653.
PMID: 27896398
The distribution, metabolism, excretion and hepatic effects of the human hepatotoxin fenclozic acid were investigated following single oral doses of 10 mg/kg to normal and bile duct-cannulated male C57BL/6J mice....
6.
Hothersall J, Guo D, Sarda S, Sheppard R, Chen H, Keur W, et al.
Mol Pharmacol
. 2016 Nov;
91(1):25-38.
PMID: 27803241
The duration of action of adenosine A receptor (A2A) agonists is critical for their clinical efficacy, and we sought to better understand how this can be optimized. The in vitro...
7.
Akingbasote J, Foster A, Wilson I, Sarda S, Jones H, Kenna J
Arch Toxicol
. 2015 Mar;
90(4):853-62.
PMID: 25820915
Hepatic NADPH-cytochrome P450 oxidoreductase null (HRN™) mice exhibit normal hepatic and extrahepatic biotransformation enzyme activities when compared to wild-type (WT) mice, but express no functional hepatic cytochrome P450 activities. When...
8.
Ballard P, Swaisland H, Malone M, Sarda S, Ghiorghiu S, Wilbraham D
Xenobiotica
. 2014 Jul;
44(12):1083-98.
PMID: 25007130
1. This series of studies in rats, dogs and humans (Clinicaltrials.gov identifier: NCT01284595) investigated the pharmacokinetics, tissue distribution, metabolism and excretion of the EGFR, HER2 and HER3 signalling inhibitor AZD8931....
9.
Samuelsson K, Pickup K, Sarda S, Foster J, Randall K, Abrahamsson A, et al.
Xenobiotica
. 2014 Jan;
44(2):186-95.
PMID: 24417752
1. The biotransformation, hepatic transporter and blood chemistry effects of troglitazone were investigated following 7 days of dosing at 600 mg/kg/day to chimeric murinized or humanized FRG mice, Mo-FRG and...
10.
Pickup K, Wills J, Rodrigues A, Jones H, Page C, Martin S, et al.
Xenobiotica
. 2013 Dec;
44(2):164-73.
PMID: 24320884
1. The distribution, metabolism, excretion and hepatic effects of fenclozic acid were investigated following a single oral dose of 10 mg/kg to hepatic reductase null (HRN) mice. 2. The majority...