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Mathias A Bohme

Explore the profile of Mathias A Bohme including associated specialties, affiliations and a list of published articles. Areas
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Articles 16
Citations 456
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Recent Articles
1.
Jusyte M, Blaum N, Bohme M, Berns M, Bonard A, Vamosi A, et al.
Cell Rep . 2023 May; 42(6):112541. PMID: 37243591
Presynaptic plasticity adjusts neurotransmitter (NT) liberation. Short-term facilitation (STF) tunes synapses to millisecond repetitive activation, while presynaptic homeostatic potentiation (PHP) of NT release stabilizes transmission over minutes. Despite different timescales...
2.
Gotze K, Mrestani A, Beckmann P, Krohn K, Le Duc D, Velluva A, et al.
Biol Methods Protoc . 2022 Jan; 7(1):bpac003. PMID: 35087953
The precise and rapid construction of alleles through CRISPR/Cas9-mediated genome engineering renders a powerful animal system for molecular structure-function analyses and human disease models. Application of the co-selection method offers...
3.
Bohme M, McCarthy A, Blaum N, Berezeckaja M, Ponimaskine K, Schwefel D, et al.
Glia . 2021 Apr; 69(8):1897-1915. PMID: 33811396
Peripheral nerves contain sensory and motor neuron axons coated by glial cells whose interplay ensures function, but molecular details are lacking. SNARE-proteins mediate the exchange and secretion of cargo by...
4.
Ramesh N, Escher M, Mampell M, Bohme M, Gotz T, Goel P, et al.
Curr Biol . 2021 Mar; 31(8):1711-1725.e5. PMID: 33651992
As a result of developmental synapse formation, the presynaptic neurotransmitter release machinery becomes accurately matched with postsynaptic neurotransmitter receptors. Trans-synaptic signaling is executed through cell adhesion proteins such as Neurexin::Neuroligin...
5.
Kobbersmed J, Grasskamp A, Jusyte M, Bohme M, Ditlevsen S, Sorensen J, et al.
Elife . 2020 Feb; 9. PMID: 32077852
Chemical synaptic transmission relies on the Ca-induced fusion of transmitter-laden vesicles whose coupling distance to Ca channels determines synaptic release probability and short-term plasticity, the facilitation or depression of repetitive...
6.
Goel P, Dufour Bergeron D, Bohme M, Nunnelly L, Lehmann M, Buser C, et al.
J Cell Biol . 2019 Mar; 218(5):1706-1724. PMID: 30914419
Synaptic terminals grow and retract throughout life, yet synaptic strength is maintained within stable physiological ranges. To study this process, we investigated () mutants. Although active zone (AZ) number is...
7.
Bohme M, McCarthy A, Grasskamp A, Beuschel C, Goel P, Jusyte M, et al.
Nat Commun . 2019 Mar; 10(1):1085. PMID: 30842428
Neuronal communication across synapses relies on neurotransmitter release from presynaptic active zones (AZs) followed by postsynaptic transmitter detection. Synaptic plasticity homeostatically maintains functionality during perturbations and enables memory formation. Postsynaptic...
8.
Bohme M, Grasskamp A, Walter A
FEBS Lett . 2018 Jul; 592(21):3516-3531. PMID: 29993122
Synaptic transmission relies on the rapid fusion of neurotransmitter-containing synaptic vesicles (SVs), which happens in response to action potential (AP)-induced Ca influx at active zones (AZs). A highly conserved molecular...
9.
Walter A, Bohme M, Sigrist S
Neurosci Res . 2017 Dec; 127:3-13. PMID: 29275162
Information transfer between nerve cells (neurons) forms the basis of behavior, emotion, and survival. Signal transduction from one neuron to another occurs at synapses, and relies on both electrical and...
10.
Reddy-Alla S, Bohme M, Reynolds E, Beis C, Grasskamp A, Mampell M, et al.
Neuron . 2017 Sep; 95(6):1350-1364.e12. PMID: 28867551
Neural information processing depends on precisely timed, Ca-activated synaptic vesicle exocytosis from release sites within active zones (AZs), but molecular details are unknown. Here, we identify that the (M)Unc13-family member...